| 2021-05-10 | NorrkopingvAIKAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2021-05-10 | Newells Old BoysvSarmiento JuninCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-05-10 | VallecanovLeganesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-05-10 | RakowvPiast GliwiceEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-05-10 | PordenonevCosenzaSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-05-10 | BetisvGranadaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-05-10 | HebeivShanghai ShenhuaSuper League · China | 1–1 | Super League · China |
| 2021-05-10 | ChievovAscoliSerie B · Italy | 3–0 | Serie B · Italy |
| 2021-05-10 | Spartak MoscowvKhimkiPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-05-10 | FC VoluntarivChindia TargovisteSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-05-10 | PisavVirtus EntellaSerie B · Italy | 3–2 | Serie B · Italy |
| 2021-05-10 | RegginavFrosinoneSerie B · Italy | 0–4 | Serie B · Italy |
| 2021-05-10 | UralvFK RostovPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-05-10 | MonzavBresciaSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-05-10 | FCSBvAcademica ClinceniSuperliga · Romania | 2–2 | Superliga · Romania |
| 2021-05-10 | HamburgvNurnberg2. Bundesliga · Germany | 5–2 | 2. Bundesliga · Germany |
| 2021-05-10 | CittadellavVeneziaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-05-10 | PachucavGuadalajara ChivasLiga MX · Mexico | 4–2 | Liga MX · Mexico |
| 2021-05-10 | SpalvCremoneseSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-05-10 | PortimonensevMoreirensePrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-05-10 | FulhamvBurnleyPremier League · England | 0–2 | Premier League · England |
| 2021-05-10 | CFR ClujvSepsi Sf. GheorgheSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-05-10 | Sporting Kansas CityvAustin FCMLS · United States | 2–1 | MLS · United States |
| 2021-05-09 | VejlevSonderjyskeSuperliga · Denmark | 4–2 | Superliga · Denmark |
| 2021-05-09 | BochumvRegensburg2. Bundesliga · Germany | 5–1 | 2. Bundesliga · Germany |
| 2021-05-09 | LyngbyvHorsensSuperliga · Denmark | 3–4 | Superliga · Denmark |
| 2021-05-09 | GillinghamvPlymouthLeague One · England | 1–0 | League One · England |
| 2021-05-09 | LanusvTalleres CordobaCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-09 | MoldevKristiansundEliteserien · Norway | 2–0 | Eliteserien · Norway |
| 2021-05-09 | Portland TimbersvSeattle SoundersMLS · United States | 1–2 | MLS · United States |
| 2021-05-09 | ValerengavRosenborgEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-05-09 | River PlatevAldosiviCopa De La Liga Profesional · Argentina | 4–1 | Copa De La Liga Profesional · Argentina |
| 2021-05-09 | Colon Santa FEvUnion de Santa FeCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-05-09 | OviedovSabadellLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-05-09 | WolvesvBrightonPremier League · England | 2–1 | Premier League · England |
| 2021-05-09 | Viitorul ConstantavFC ArgesSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-05-09 | DegerforsvDjurgardenAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2021-05-09 | Kashima AntlersvFC TokyoJ1 League · Japan | 3–0 | J1 League · Japan |
| 2021-05-09 | FC EmmenvGroningenEredivisie · Netherlands | 0–4 | Eredivisie · Netherlands |
| 2021-05-09 | WiganvSwindonLeague One · England | 3–4 | League One · England |
| 2021-05-09 | MariehamnvAC OuluVeikkausliiga · Finland | 3–1 | Veikkausliiga · Finland |
| 2021-05-09 | Erzgebirge AuevPaderborn2. Bundesliga · Germany | 3–8 | 2. Bundesliga · Germany |
| 2021-05-09 | AngersvDijonLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-05-09 | ZwollevDen HaagEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-05-09 | St EtiennevMarseilleLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-05-09 | RennesvParis SGLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-05-09 | HerthavBielefeldBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-05-09 | ParmavAtalantaSerie A · Italy | 2–5 | Serie A · Italy |
| 2021-05-09 | VikingvBrannEliteserien · Norway | 3–1 | Eliteserien · Norway |
| 2021-05-09 | PortsmouthvAccringtonLeague One · England | 0–1 | League One · England |