| 2021-12-05 | BahiavFluminenseSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-12-05 |  Singaporev MyanmarAFF Championship | 3–0 | AFF Championship |
| 2021-12-05 | ValerengavMjondalenEliteserien · Norway | 2–0 | Eliteserien · Norway |
| 2021-12-05 | SampdoriavLazioSerie A · Italy | 1–3 | Serie A · Italy |
| 2021-12-05 | MechelenvGenkPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-12-05 | Las PalmasvSp GijonLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-12-05 | IndependientevSan LorenzoLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-12-05 | HeidenheimvRegensburg2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-12-05 | Atletico-MGvBragantinoSerie A · Brazil | 4–3 | Serie A · Brazil |
| 2021-12-05 | StuttgartvHerthaBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-12-05 |  Timor-Lestev ThailandAFF Championship | 0–2 | AFF Championship |
| 2021-12-05 | Dundee UnitedvCelticPremiership · Scotland | 0–3 | Premiership · Scotland |
| 2021-12-05 | StabaekvRosenborgEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2021-12-05 | Man UnitedvCrystal PalacePremier League · England | 1–0 | Premier League · England |
| 2021-12-05 | Dynamo MoscowvUfaPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-12-05 | Sarpsborg 08vTromsoEliteserien · Norway | 0–1 | Eliteserien · Norway |
| 2021-12-05 | SpeziavSassuoloSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-12-05 | MalagavAmorebietaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-12-05 | QPRvStokeChampionship · England | 0–2 | Championship · England |
| 2021-12-05 | DresdenvKarlsruhe2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-12-05 | BaselvLausanneSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-12-05 | CracoviavLegiaEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-12-05 | Go Ahead EaglesvTwenteEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-12-05 | LevantevOsasunaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-12-05 | SK RapidvAustria ViennaBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-12-05 | VeneziavVeronaSerie A · Italy | 3–4 | Serie A · Italy |
| 2021-12-05 | Sociedad BvBurgosLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-12-05 | AZ AlkmaarvSparta RotterdamEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-12-05 | HataysporvBuyuksehyrSüper Lig · Turkey | 0–3 | Süper Lig · Turkey |
| 2021-12-05 | LanusvRosario CentralLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2021-12-05 | GiresunsporvKaragumrukSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-12-05 | ReimsvAngersLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-12-05 | Santa ClaravAroucaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-12-05 | AnderlechtvWaregemPro League · Belgium | 3–2 | Pro League · Belgium |
| 2021-12-05 | HannovervHamburg2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-12-05 | ArisvAsteras TripolisSuper League · Greece | 1–0 | Super League · Greece |
| 2021-12-05 | BolognavFiorentinaSerie A · Italy | 2–3 | Serie A · Italy |
| 2021-12-05 | MontpelliervClermontLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-12-05 | U Craiova 1948vFC VoluntariSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-12-05 | CeltavValenciaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-12-05 | IonikosvPAOKSuper League · Greece | 3–2 | Super League · Greece |
| 2021-12-05 | Gimnasia L.P.vEstudiantes L.P.Liga Profesional · Argentina | 4–4 | Liga Profesional · Argentina |
| 2021-12-05 | BresciavMonzaSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-12-05 | VikingvOddEliteserien · Norway | 3–1 | Eliteserien · Norway |
| 2021-12-05 | LASKvRiedBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2021-12-05 | St. GallenvGrasshoppersSuper League · Switzerland | 0–4 | Super League · Switzerland |
| 2021-12-05 | SandefjordvKristiansundEliteserien · Norway | 3–2 | Eliteserien · Norway |
| 2021-12-05 | CearavAmerica MGSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-12-05 | ZaglebievLech PoznanEkstraklasa · Poland | 2–3 | Ekstraklasa · Poland |
| 2021-12-05 | LivingstonvHeartsPremiership · Scotland | 0–1 | Premiership · Scotland |