| 2022-04-30 | AugsburgvFC KolnBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2022-04-30 | ShrewsburyvWiganLeague One · England | 0–3 | League One · England |
| 2022-04-30 | BarnetvGrimsbyNational League · England | 2–2 | National League · England |
| 2022-04-30 | MillwallvPeterboroChampionship · England | 3–0 | Championship · England |
| 2022-04-30 | RegginavComoSerie B · Italy | 1–4 | Serie B · Italy |
| 2022-04-30 | BoltonvFleetwood TownLeague One · England | 4–2 | League One · England |
| 2022-04-30 | LivingstonvHibernianPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2022-04-30 | CoventryvHuddersfieldChampionship · England | 1–2 | Championship · England |
| 2022-04-30 | WolvesvBrightonPremier League · England | 0–3 | Premier League · England |
| 2022-04-30 | NapolivSassuoloSerie A · Italy | 6–1 | Serie A · Italy |
| 2022-04-30 | TrabzonsporvAntalyasporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2022-04-30 | LeedsvMan CityPremier League · England | 0–4 | Premier League · England |
| 2022-04-30 | ZaglebievLechia GdanskEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2022-04-30 | MorecambevSunderlandLeague One · England | 0–1 | League One · England |
| 2022-04-30 | Real MadridvEspanolLa Liga · Spain | 4–0 | La Liga · Spain |
| 2022-04-30 | WealdstonevDag and RedNational League · England | 1–2 | National League · England |
| 2022-04-30 | GuingampvCaenLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-30 | AjacciovLe HavreLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-30 | ValenciavLevanteLa Liga · Spain | 1–1 | La Liga · Spain |
| 2022-04-30 | BurtonvWycombeLeague One · England | 1–2 | League One · England |
| 2022-04-30 | CearavBragantinoSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2022-04-30 | NecaxavGuadalajara ChivasLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-04-30 | AroucavPortimonensePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2022-04-30 | RochdalevBristol RvsLeague Two · England | 3–4 | League Two · England |
| 2022-04-30 | Nott'm ForestvSwanseaChampionship · England | 5–1 | Championship · England |
| 2022-04-30 | BelenensesvSp BragaPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-04-30 | BurgosvAlmeriaLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2022-04-30 | IngolstadtvHamburg2. Bundesliga · Germany | 0–4 | 2. Bundesliga · Germany |
| 2022-04-30 | DresdenvRegensburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-04-30 | Stal MielecvLegiaEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2022-04-30 | AFC WimbledonvAccringtonLeague One · England | 3–4 | League One · England |
| 2022-04-30 | OFI CretevPanetolikosSuper League · Greece | 0–1 | Super League · Greece |
| 2022-04-30 | Toronto FCvFC CincinnatiMLS · United States | 1–2 | MLS · United States |
| 2022-04-30 | CremonesevAscoliSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-04-30 | NorthamptonvExeterLeague Two · England | 1–1 | League Two · England |
| 2022-04-30 | SouthamptonvCrystal PalacePremier League · England | 1–2 | Premier League · England |
| 2022-04-30 | AlavesvVillarrealLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-04-29 | StrasbourgvParis SGLigue 1 · France | 3–3 | Ligue 1 · France |
| 2022-04-29 | Gornik Z.vRadomiak RadomEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2022-04-29 | Sepsi Sf. GheorghevGaz Metan MediasSuperliga · Romania | 3–1 | Superliga · Romania |
| 2022-04-29 | Shimizu S-PulsevSanfrecce HiroshimaJ1 League · Japan | 2–2 | J1 League · Japan |
| 2022-04-29 | ArbroathvMortonChampionship · Scotland | 3–0 | Championship · Scotland |
| 2022-04-29 | Hokkaido Consadole SapporovShonan BellmareJ1 League · Japan | 1–0 | J1 League · Japan |
| 2022-04-29 | Chindia TargovistevFC Rapid BucurestiSuperliga · Romania | 0–0 | Superliga · Romania |
| 2022-04-29 | AC OuluvHakaVeikkausliiga · Finland | 3–0 | Veikkausliiga · Finland |
| 2022-04-29 | Raith RvsvKilmarnockChampionship · Scotland | 1–1 | Championship · Scotland |
| 2022-04-29 | SevillavCadizLa Liga · Spain | 1–1 | La Liga · Spain |
| 2022-04-29 | Werder BremenvHolstein Kiel2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2022-04-29 | DunfermlinevQueen of SthChampionship · Scotland | 1–2 | Championship · Scotland |
| 2022-04-29 | KyotovAvispa FukuokaJ1 League · Japan | 0–1 | J1 League · Japan |