| 2021-05-13 | PSV EindhovenvZwolleEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2021-05-13 | Holstein KielvRegensburg2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-05-13 | FC EmmenvHeerenveenEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-05-13 | HeraclesvFeyenoordEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-05-13 | AIKvMalmo FFAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-05-13 | For SittardvVitesseEredivisie · Netherlands | 3–3 | Eredivisie · Netherlands |
| 2021-05-13 | San Jose EarthquakesvSeattle SoundersMLS · United States | 0–1 | MLS · United States |
| 2021-05-13 | Man UnitedvLiverpoolPremier League · England | 2–4 | Premier League · England |
| 2021-05-13 | RosenborgvVikingEliteserien · Norway | 5–0 | Eliteserien · Norway |
| 2021-05-13 | TromsovMoldeEliteserien · Norway | 3–3 | Eliteserien · Norway |
| 2021-05-13 | ValladolidvVillarrealLa Liga · Spain | 0–2 | La Liga · Spain |
| 2021-05-13 | EibarvBetisLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-05-13 | CrotonevVeronaSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-05-13 | Philadelphia UnionvNew England RevolutionMLS · United States | 1–1 | MLS · United States |
| 2021-05-12 | BrannvValerengaEliteserien · Norway | 0–3 | Eliteserien · Norway |
| 2021-05-12 | Kawasaki FrontalevVegalta SendaiJ1 League · Japan | 2–2 | J1 League · Japan |
| 2021-05-12 | ZurichvSt. GallenSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2021-05-12 | ServettevLausanneSuper League · Switzerland | 1–4 | Super League · Switzerland |
| 2021-05-12 | GuimaraesvFamalicaoPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-05-12 | SionvLuzernSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-05-12 | VarbergvHammarbyAllsvenskan · Sweden | 1–3 | Allsvenskan · Sweden |
| 2021-05-12 | Nagoya GrampusvKashima AntlersJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-05-12 | KristiansundvBodo/GlimtEliteserien · Norway | 0–2 | Eliteserien · Norway |
| 2021-05-12 | AberdeenvHibernianPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-05-12 | SalzburgvSK RapidBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2021-05-12 | Dundee UnitedvMotherwellPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2021-05-12 | Asteras TripolisvAEKSuper League · Greece | 1–1 | Super League · Greece |
| 2021-05-12 | DjurgardenvOstersundsAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2021-05-12 | ArisvPanathinaikosSuper League · Greece | 0–0 | Super League · Greece |
| 2021-05-12 | Gamba OsakavSanfrecce HiroshimaJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-05-12 | SevillavValenciaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-05-12 | ChelseavArsenalPremier League · England | 0–1 | Premier League · England |
| 2021-05-12 | AtalantavBeneventoSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-05-12 | SampdoriavSpeziaSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-05-12 | HuescavAth BilbaoLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-05-12 | KalmarvGoteborgAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-05-12 | SiriusvElfsborgAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2021-05-12 | SassuolovJuventusSerie A · Italy | 1–3 | Serie A · Italy |
| 2021-05-12 | LivingstonvRangersPremiership · Scotland | 0–3 | Premiership · Scotland |
| 2021-05-12 | TirolvSturm GrazBundesliga · Austria | 2–3 | Bundesliga · Austria |
| 2021-05-12 | CeltavGetafeLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-05-12 | BolognavGenoaSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-05-12 | HackenvOrebroAllsvenskan · Sweden | 2–3 | Allsvenskan · Sweden |
| 2021-05-12 | Wolfsberger ACvLASKBundesliga · Austria | 0–4 | Bundesliga · Austria |
| 2021-05-12 | ToulousevPau FCLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-05-12 | OlympiakosvPAOKSuper League · Greece | 1–0 | Super League · Greece |
| 2021-05-12 | TorinovMilanSerie A · Italy | 0–7 | Serie A · Italy |
| 2021-05-12 | IntervRomaSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-05-12 | Schalke 04vHerthaBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-05-12 | KilmarnockvSt MirrenPremiership · Scotland | 3–3 | Premiership · Scotland |