| 2026-02-21 | MantovavSampdoriaSerie B · Italy | 2–1 | Serie B · Italy |
| 2026-02-21 | MoreirensevSp LisbonPrimeira Liga · Portugal | 0–3 | Primeira Liga · Portugal |
| 2026-02-21 | MansfieldvLincolnLeague One · England | 0–2 | League One · England |
| 2026-02-21 | HuddersfieldvBarnsleyLeague One · England | 2–1 | League One · England |
| 2026-02-21 | LutonvBurtonLeague One · England | 1–1 | League One · England |
| 2026-02-21 | BanfieldvNewells Old BoysLiga Profesional · Argentina | 3–0 | Liga Profesional · Argentina |
| 2026-02-21 | AlmeriavCordobaLaLiga 2 · Spain | 2–1 | LaLiga 2 · Spain |
| 2026-02-21 | Paris SGvMetzLigue 1 · France | 3–0 | Ligue 1 · France |
| 2026-02-21 | StokevLeicesterChampionship · England | 2–2 | Championship · England |
| 2026-02-21 | NorwichvBirminghamChampionship · England | 1–2 | Championship · England |
| 2026-02-21 | VeneziavPescaraSerie B · Italy | 3–2 | Serie B · Italy |
| 2026-02-21 | Tigres UANLvPachucaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2026-02-21 | StranraervSpartansLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2026-02-21 | TroyesvPau FCLigue 2 · France | 4–3 | Ligue 2 · France |
| 2026-02-21 | La CorunavEibarLaLiga 2 · Spain | 1–0 | LaLiga 2 · Spain |
| 2026-02-21 | St EtiennevLavalLigue 2 · France | 2–1 | Ligue 2 · France |
| 2026-02-21 | AltrinchamvBraintree TownNational League · England | 2–1 | National League · England |
| 2026-02-21 | FC KolnvHoffenheimBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2026-02-21 | WrexhamvIpswichChampionship · England | 5–3 | Championship · England |
| 2026-02-21 | Boston UtdvTamworthNational League · England | 0–0 | National League · England |
| 2026-02-21 | East KilbridevDumbartonLeague Two · Scotland | 3–1 | League Two · Scotland |
| 2026-02-21 | LeccevInterSerie A · Italy | 0–2 | Serie A · Italy |
| 2026-02-21 | YorkvHalifaxNational League · England | 4–1 | National League · England |
| 2026-02-21 | St MirrenvMotherwellPremiership · Scotland | 0–5 | Premiership · Scotland |
| 2026-02-21 | DarmstadtvFortuna Dusseldorf2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2026-02-21 | HuescavMirandesLaLiga 2 · Spain | 1–2 | LaLiga 2 · Spain |
| 2026-02-21 | Boreham WoodvForest GreenNational League · England | 1–1 | National League · England |
| 2026-02-21 | TrurovGatesheadNational League · England | 1–2 | National League · England |
| 2026-02-21 | BoltonvBlackpoolLeague One · England | 2–2 | League One · England |
| 2026-02-21 | Asteras TripolisvAtromitosSuper League Greece · Greece | 1–2 | Super League Greece · Greece |
| 2026-02-21 | SouthamptonvCharltonChampionship · England | 1–1 | Championship · England |
| 2026-02-21 | Notts CountyvTranmereLeague Two · England | 5–0 | League Two · England |
| 2026-02-21 | SolihullvHartlepoolNational League · England | 3–4 | National League · England |
| 2026-02-21 | Ind. RivadaviavIndependienteLiga Profesional · Argentina | 3–2 | Liga Profesional · Argentina |
| 2026-02-21 | Fleetwood TownvBarrowLeague Two · England | 3–2 | League Two · England |
| 2026-02-21 | Man CityvNewcastlePremier League · England | 2–1 | Premier League · England |
| 2026-02-21 | ArbroathvDunfermlineChampionship · Scotland | 4–2 | Championship · Scotland |
| 2026-02-21 | Queens ParkvMortonChampionship · Scotland | 3–2 | Championship · Scotland |
| 2026-02-21 | PueblavClub AmericaLiga MX · Mexico | 0–4 | Liga MX · Mexico |
| 2026-02-21 | ForfarvAnnan AthleticLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2026-02-21 | SK RapidvWolfsberger ACAustrian Bundesliga · Austria | 2–0 | Austrian Bundesliga · Austria |
| 2026-02-21 | MontrosevQueen of SthLeague One · Scotland | 3–2 | League One · Scotland |
| 2026-02-21 | BenficavAVSPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2026-02-21 | AberdeenvDundeePremiership · Scotland | 2–3 | Premiership · Scotland |
| 2026-02-21 | AlanyasporvBuyuksehyrSüper Lig · Türkiye | 1–2 | Süper Lig · Türkiye |
| 2026-02-21 | EyupsporvGenclerbirligiSüper Lig · Türkiye | 1–0 | Süper Lig · Türkiye |
| 2026-02-21 | Schalke 04vMagdeburg2. Bundesliga · Germany | 5–3 | 2. Bundesliga · Germany |
| 2026-02-21 | CagliarivLazioSerie A · Italy | 0–0 | Serie A · Italy |
| 2026-02-21 | Bristol RvsvGrimsbyLeague Two · England | 3–1 | League Two · England |
| 2026-02-21 | GrasshoppersvZurichSwiss Super League · Switzerland | 1–2 | Swiss Super League · Switzerland |