| 2022-04-30 | SpeziavLazioSerie A · Italy | 3–4 | Serie A · Italy |
| 2022-04-30 | StockportvBoreham WoodNational League · England | 1–2 | National League · England |
| 2022-04-30 | LuganovGrasshoppersSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2022-04-30 | PlymouthvMilton Keynes DonsLeague One · England | 0–5 | League One · England |
| 2022-04-30 | Kings LynnvEastleighNational League · England | 3–3 | National League · England |
| 2022-04-30 | BlackpoolvDerbyChampionship · England | 0–2 | Championship · England |
| 2022-04-30 | StirlingvEdinburgh CityLeague Two · Scotland | 5–0 | League Two · Scotland |
| 2022-04-30 | IpswichvCharltonLeague One · England | 4–0 | League One · England |
| 2022-04-30 | GillinghamvRotherhamLeague One · England | 0–2 | League One · England |
| 2022-04-30 | SwindonvBarrowLeague Two · England | 2–1 | League Two · England |
| 2022-04-30 | PordenonevCrotoneSerie B · Italy | 3–3 | Serie B · Italy |
| 2022-04-30 | WeymouthvSolihullNational League · England | 2–4 | National League · England |
| 2022-04-30 | CardiffvBirminghamChampionship · England | 1–1 | Championship · England |
| 2022-04-30 | MonzavBeneventoSerie B · Italy | 3–0 | Serie B · Italy |
| 2022-04-30 | TorquayvMaidenheadNational League · England | 1–1 | National League · England |
| 2022-04-30 | Paris FCvValenciennesLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-04-30 | Hansa RostockvPaderborn2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2022-04-30 | Queens ParkvFalkirkLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-04-30 | Atl. TucumanvTalleres CordobaCopa De La Liga Profesional · Argentina | 3–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-30 | East FifevCove RangersLeague One · Scotland | 2–3 | League One · Scotland |
| 2022-04-30 | TernanavPerugiaSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-04-30 | OxfordvDoncasterLeague One · England | 1–1 | League One · England |
| 2022-04-30 | WatfordvBurnleyPremier League · England | 1–2 | Premier League · England |
| 2022-04-30 | RennesvSt EtienneLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-04-30 | ZenitvLokomotiv MoscowPremier League · Russia | 3–1 | Premier League · Russia |
| 2022-04-30 | CowdenbeathvAlbion RvsLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2022-04-30 | HoffenheimvFreiburgBundesliga · Germany | 3–4 | Bundesliga · Germany |
| 2022-04-30 | SochauxvBastiaLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-30 | ReadingvWest BromChampionship · England | 0–1 | Championship · England |
| 2022-04-30 | St JohnstonevSt MirrenPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2022-04-30 | Dundee UnitedvMotherwellPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2022-04-30 | GoiasvAtletico-MGSerie A · Brazil | 2–2 | Serie A · Brazil |
| 2022-04-30 | CittadellavBresciaSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-04-30 | SpalvFrosinoneSerie B · Italy | 3–0 | Serie B · Italy |
| 2022-04-30 | Velez SarsfieldvTigreCopa De La Liga Profesional · Argentina | 3–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-30 | DjurgardenvSiriusAllsvenskan · Sweden | 4–0 | Allsvenskan · Sweden |
| 2022-04-30 | PortovVizelaPrimeira Liga · Portugal | 4–2 | Primeira Liga · Portugal |
| 2022-04-30 | ScunthorpevHartlepoolLeague Two · England | 1–1 | League Two · England |
| 2022-04-30 | Crawley TownvLeyton OrientLeague Two · England | 0–2 | League Two · England |
| 2022-04-30 | AjaxvZwolleEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2022-04-30 | StranraervElginLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2022-04-30 | America MGvAthletico-PRSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2022-04-30 | BlackburnvBournemouthChampionship · England | 0–3 | Championship · England |
| 2022-04-30 | Dover AthleticvAltrinchamNational League · England | 0–1 | National League · England |
| 2022-04-30 | NewcastlevLiverpoolPremier League · England | 0–1 | Premier League · England |
| 2022-04-30 | AldershotvNotts CountyNational League · England | 3–1 | National League · England |
| 2022-04-30 | ServettevSt. GallenSuper League · Switzerland | 0–2 | Super League · Switzerland |
| 2022-04-30 | VikingvHaugesundEliteserien · Norway | 5–1 | Eliteserien · Norway |
| 2022-04-30 | Forest GreenvHarrogateLeague Two · England | 1–3 | League Two · England |
| 2022-04-30 | Racing ClubvBanfieldCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |