| 2021-05-15 | RomavLazioSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-05-15 | Qingdao FCvChongqing Liangjiang AthleticSuper League · China | 1–0 | Super League · China |
| 2021-05-15 | ChateaurouxvAjaccioLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-05-15 | HartbergvAdmiraBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2021-05-15 | GoztepvBesiktasSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-05-15 | HibernianvCelticPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-05-15 | LuganovSionSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2021-05-15 | Boreham WoodvWrexhamNational League · England | 2–3 | National League · England |
| 2021-05-15 | AldershotvHartlepoolNational League · England | 1–3 | National League · England |
| 2021-05-15 | Rio AvevPortoPrimeira Liga · Portugal | 0–3 | Primeira Liga · Portugal |
| 2021-05-15 | EastleighvBarnetNational League · England | 3–0 | National League · England |
| 2021-05-15 | NancyvAmiensLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-05-15 | HIFKvIlvesVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2021-05-15 | GrenoblevRodezLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-05-15 | SivassporvKasimpasaSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-05-15 | Vissel KobevCerezo OsakaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-05-15 | FarensevTondelaPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-05-15 | Yokohama FCvShonan BellmareJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-05-14 | Santos LagunavMonterreyLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-05-14 | DC UnitedvChicago FireMLS · United States | 1–0 | MLS · United States |
| 2021-05-14 | Sp BragavMoreirensePrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-05-14 | ShenzhenvShandong TaishanSuper League · China | 2–2 | Super League · China |
| 2021-05-14 | PachucavClub AmericaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-05-14 | EspanolvCartagenaLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-05-14 | HonkavInter TurkuVeikkausliiga · Finland | 1–2 | Veikkausliiga · Finland |
| 2021-05-14 | VejlevOdenseSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-05-14 | NewcastlevMan CityPremier League · England | 3–4 | Premier League · England |
| 2021-05-14 | Guangzhou CityvCangzhouSuper League · China | 0–0 | Super League · China |
| 2021-05-14 | KuPSvMariehamnVeikkausliiga · Finland | 2–0 | Veikkausliiga · Finland |
| 2021-05-14 | Finn HarpsvDundalkPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-05-14 | Pacos FerreiravGil VicentePrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-05-14 | Academica ClincenivFC BotosaniSuperliga · Romania | 4–3 | Superliga · Romania |
| 2021-05-14 | Chindia TargovistevViitorul ConstantaSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-05-14 | DroghedavSt. PatricksPremier Division · Ireland | 3–1 | Premier Division · Ireland |
| 2021-05-14 | HakavKTPVeikkausliiga · Finland | 0–3 | Veikkausliiga · Finland |
| 2021-05-13 | Aston VillavEvertonPremier League · England | 0–0 | Premier League · England |
| 2021-05-13 | TolucavCruz AzulLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-05-13 | Inter MiamivCF MontrealMLS · United States | 0–2 | MLS · United States |
| 2021-05-13 | HalmstadvMjallbyAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-05-13 | AtlasvPueblaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-05-13 | GranadavReal MadridLa Liga · Spain | 1–4 | La Liga · Spain |
| 2021-05-13 | WaalwijkvTwenteEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-05-13 | Toronto FCvColumbus CrewMLS · United States | 2–0 | MLS · United States |
| 2021-05-13 | GroningenvAZ AlkmaarEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-05-13 | Minnesota UnitedvVancouver WhitecapsMLS · United States | 1–0 | MLS · United States |
| 2021-05-13 | Den HaagvWillem IIEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2021-05-13 | NorrkopingvDegerforsAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-05-13 | AjaxvVVV VenloEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-05-13 | Sparta RotterdamvUtrechtEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-05-13 | Houston DynamovSporting Kansas CityMLS · United States | 1–0 | MLS · United States |