| 2022-04-30 | Airdrie UtdvPeterheadLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-04-30 | DortmundvBochumBundesliga · Germany | 3–4 | Bundesliga · Germany |
| 2022-04-30 | Annan AthleticvKelty HeartsLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2022-04-30 | LincolnvCreweLeague One · England | 2–1 | League One · England |
| 2022-04-30 | AlloavMontroseLeague One · Scotland | 4–1 | League One · Scotland |
| 2022-04-30 | KasimpasavBuyuksehyrSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2022-04-30 | Mazatlan FCvPueblaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-04-30 | ForfarvStenhousemuirLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2022-04-30 | Real Salt LakevLos Angeles GalaxyMLS · United States | 1–0 | MLS · United States |
| 2022-04-30 | DarmstadtvErzgebirge Aue2. Bundesliga · Germany | 6–0 | 2. Bundesliga · Germany |
| 2022-04-30 | HataysporvAltaySüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2022-04-30 | Univ. CraiovavFC VoluntariSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-04-30 | Sheffield WedsvPortsmouthLeague One · England | 4–1 | League One · England |
| 2022-04-30 | AberdeenvDundeePremiership · Scotland | 1–0 | Premiership · Scotland |
| 2022-04-30 | CarlislevStevenageLeague Two · England | 2–1 | League Two · England |
| 2022-04-30 | NancyvNimesLigue 2 · France | 1–3 | Ligue 2 · France |
| 2022-04-30 | Sparta RotterdamvAZ AlkmaarEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-04-30 | DumbartonvClydeLeague One · Scotland | 2–1 | League One · Scotland |
| 2022-04-30 | StuttgartvWolfsburgBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-04-30 | HeartsvRoss CountyPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2022-04-30 | TranmerevOldhamLeague Two · England | 2–0 | League Two · England |
| 2022-04-30 | BarnsleyvPrestonChampionship · England | 1–3 | Championship · England |
| 2022-04-30 | GrenoblevAmiensLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-04-30 | MaritimovBenficaPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-04-30 | PisavCosenzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-04-30 | KrasnodarvFK RostovPremier League · Russia | 2–1 | Premier League · Russia |
| 2022-04-30 | Aston VillavNorwichPremier League · England | 2–0 | Premier League · England |
| 2022-04-30 | BielefeldvHerthaBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-04-30 | CagliarivVeronaSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-04-30 | OviedovMirandesLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2022-04-30 | EibarvZaragozaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2022-04-30 | AuxerrevDunkerqueLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-04-30 | Houston DynamovAustin FCMLS · United States | 1–2 | MLS · United States |
| 2022-04-30 | Volos NFCvAtromitosSuper League · Greece | 1–1 | Super League · Greece |
| 2022-04-30 | Boca JuniorsvBarracas CentralCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-30 | VicenzavLecceSerie B · Italy | 2–1 | Serie B · Italy |
| 2022-04-30 | HeraclesvTwenteEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-04-30 | HalifaxvYeovilNational League · England | 1–0 | National League · England |
| 2022-04-30 | BromleyvChesterfieldNational League · England | 4–2 | National League · England |
| 2022-04-30 | Rubin KazanvSochiPremier League · Russia | 0–6 | Premier League · Russia |
| 2022-04-30 | ParmavAlessandriaSerie B · Italy | 2–2 | Serie B · Italy |
| 2022-04-30 | CF MontrealvAtlanta UtdMLS · United States | 2–1 | MLS · United States |
| 2022-04-30 | MiddlesbroughvStokeChampionship · England | 3–1 | Championship · England |
| 2022-04-30 | Bristol CityvHullChampionship · England | 5–0 | Championship · England |
| 2022-04-30 | JagielloniavSlask WroclawEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-04-30 | Arsenal SarandivColon Santa FECopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2022-04-30 | LensvNantesLigue 1 · France | 2–2 | Ligue 1 · France |
| 2022-04-30 | NiortvDijonLigue 2 · France | 1–3 | Ligue 2 · France |
| 2022-04-30 | SampdoriavGenoaSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-04-30 | CambridgevCheltenhamLeague One · England | 2–2 | League One · England |