| 2021-05-15 | Schalke 04vEin FrankfurtBundesliga · Germany | 4–3 | Bundesliga · Germany |
| 2021-05-15 | Las PalmasvZaragozaLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-05-15 | AstravFC VoluntariSuperliga · Romania | 0–3 | Superliga · Romania |
| 2021-05-15 | St. GallenvLausanneSuper League · Switzerland | 5–0 | Super League · Switzerland |
| 2021-05-15 | YeovilvKings LynnNational League · England | 3–1 | National League · England |
| 2021-05-15 | FreiburgvBayern MunichBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-05-15 | AtromitosvVolos NFCSuper League · Greece | 1–0 | Super League · Greece |
| 2021-05-15 | BenficavSp LisbonPrimeira Liga · Portugal | 4–3 | Primeira Liga · Portugal |
| 2021-05-15 | Dag and RedvHalifaxNational League · England | 3–0 | National League · England |
| 2021-05-15 | RangersvAberdeenPremiership · Scotland | 4–0 | Premiership · Scotland |
| 2021-05-15 | ApollonvLamiaSuper League · Greece | 0–1 | Super League · Greece |
| 2021-05-15 | Shimizu S-PulsevNagoya GrampusJ1 League · Japan | 0–3 | J1 League · Japan |
| 2021-05-15 | BurnleyvLeedsPremier League · England | 0–4 | Premier League · England |
| 2021-05-15 | SouthamptonvFulhamPremier League · England | 3–1 | Premier League · England |
| 2021-05-15 | Pau FCvValenciennesLigue 2 · France | 4–3 | Ligue 2 · France |
| 2021-05-15 | SolihullvWokingNational League · England | 2–1 | National League · England |
| 2021-05-15 | HerthavFC KolnBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-05-15 | St JohnstonevLivingstonPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-05-15 | AnkaragucuvAlanyasporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-05-15 | BrightonvWest HamPremier League · England | 1–1 | Premier League · England |
| 2021-05-15 | Los Angeles GalaxyvAustin FCMLS · United States | 2–0 | MLS · United States |
| 2021-05-15 | AC OuluvSJKVeikkausliiga · Finland | 0–2 | Veikkausliiga · Finland |
| 2021-05-15 | Kashiwa ReysolvFC TokyoJ1 League · Japan | 0–4 | J1 League · Japan |
| 2021-05-15 | LongfordvBohemiansPremier Division · Ireland | 0–2 | Premier Division · Ireland |
| 2021-05-15 | SpeziavTorinoSerie A · Italy | 4–1 | Serie A · Italy |
| 2021-05-15 | Le HavrevTroyesLigue 2 · France | 3–2 | Ligue 2 · France |
| 2021-05-15 | Austria ViennavSt. PoltenBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-05-15 | GenoavAtalantaSerie A · Italy | 3–4 | Serie A · Italy |
| 2021-05-15 | AugsburgvWerder BremenBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-05-15 | Shamrock RoversvDerry CityPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-05-15 | RizesporvBuyuksehyrSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2021-05-15 | VaduzvServetteSuper League · Switzerland | 1–3 | Super League · Switzerland |
| 2021-05-15 | Poli IasivFC HermannstadtSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-05-15 | BaselvZurichSuper League · Switzerland | 4–0 | Super League · Switzerland |
| 2021-05-15 | HataysporvGaziantepSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-05-15 | LeverkusenvUnion BerlinBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-05-15 | Univ. CraiovavCFR ClujSuperliga · Romania | 1–3 | Superliga · Romania |
| 2021-05-15 | Sligo RoversvWaterfordPremier Division · Ireland | 3–0 | Premier Division · Ireland |
| 2021-05-15 | Vegalta SendaivAvispa FukuokaJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-05-15 | Young BoysvLuzernSuper League · Switzerland | 5–2 | Super League · Switzerland |
| 2021-05-15 | OFI CretevPanetolikosSuper League · Greece | 2–2 | Super League · Greece |
| 2021-05-15 | BoavistavPortimonensePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-05-15 | M'gladbachvStuttgartBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-05-15 | Notts CountyvBromleyNational League · England | 2–2 | National League · England |
| 2021-05-15 | LugovMirandesLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-05-15 | Estudiantes L.P.vIndependienteCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-15 | GalatasarayvYeni MalatyasporSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-05-15 | DunkerquevToulouseLigue 2 · France | 3–3 | Ligue 2 · France |
| 2021-05-15 | Paris FCvChamblyLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-05-15 | KaragumrukvDenizlisporSüper Lig · Turkey | 5–1 | Süper Lig · Turkey |