| 2022-05-01 | AmorebietavFuenlabradaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-05-01 | Sp LisbonvGil VicentePrimeira Liga · Portugal | 4–1 | Primeira Liga · Portugal |
| 2022-05-01 | OdensevAarhusSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2022-05-01 | CFR ClujvFarul ConstantaSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-05-01 | Club AmericavCruz AzulLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2022-05-01 | ElchevOsasunaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2022-05-01 | LuzernvLausanneSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2022-05-01 | Colorado RapidsvPortland TimbersMLS · United States | 2–0 | MLS · United States |
| 2022-05-01 | PonferradinavCartagenaLa Liga 2 · Spain | 4–2 | La Liga 2 · Spain |
| 2022-05-01 | LorientvReimsLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-05-01 | BrestvClermontLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-05-01 | Sarmiento JuninvRiver PlateCopa De La Liga Profesional · Argentina | 0–7 | Copa De La Liga Profesional · Argentina |
| 2022-05-01 | KayserisporvBesiktasSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2022-05-01 | SundsvallvAIKAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2022-05-01 | AlcorconvGironaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2022-05-01 | AlanyasporvYeni MalatyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-05-01 | RomavBolognaSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-05-01 | Akhmat GroznyvCSKA MoscowPremier League · Russia | 2–0 | Premier League · Russia |
| 2022-05-01 | LugovTenerifeLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2022-05-01 | MidtjyllandvFC CopenhagenSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2022-05-01 | Botafogo RJvJuventudeSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2022-05-01 | InternacionalvAvaiSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2022-05-01 | MonterreyvClub TijuanaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-05-01 | U Craiova 1948vUTA AradSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-05-01 | VejlevSonderjyskeSuperliga · Denmark | 0–3 | Superliga · Denmark |
| 2022-05-01 | AtlasvTigres UANLLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-05-01 | Chicago FirevNew York Red BullsMLS · United States | 1–2 | MLS · United States |
| 2022-05-01 | OlympiakosvGianninaSuper League · Greece | 3–2 | Super League · Greece |
| 2022-05-01 | EmpolivTorinoSerie A · Italy | 1–3 | Serie A · Italy |
| 2022-05-01 | PAOKvAEKSuper League · Greece | 1–1 | Super League · Greece |
| 2022-05-01 | CracoviavWislaEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2022-05-01 | PSV EindhovenvWillem IIEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2022-05-01 | West HamvArsenalPremier League · England | 1–2 | Premier League · England |
| 2022-05-01 | CelticvRangersPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-05-01 | MoreirensevBoavistaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2022-05-01 | Sporting Kansas CityvFC DallasMLS · United States | 2–2 | MLS · United States |
| 2022-05-01 | BordeauxvNiceLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-05-01 | Go Ahead EaglesvVitesseEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-04-30 | Din. BucurestivAcademica ClinceniSuperliga · Romania | 5–1 | Superliga · Romania |
| 2022-04-30 | SuttonvBradfordLeague Two · England | 1–4 | League Two · England |
| 2022-04-30 | Quevilly RouenvPau FCLigue 2 · France | 1–2 | Ligue 2 · France |
| 2022-04-30 | KonyasporvKaragumrukSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2022-04-30 | QueretarovJuarezLiga MX · Mexico | 4–0 | Liga MX · Mexico |
| 2022-04-30 | CuiabavAtletico GOSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2022-04-30 | WrexhamvSouthendNational League · England | 1–0 | National League · England |
| 2022-04-30 | Ath BilbaovAth MadridLa Liga · Spain | 2–0 | La Liga · Spain |
| 2022-04-30 | PatronatovGimnasia L.P.Copa De La Liga Profesional · Argentina | 0–6 | Copa De La Liga Profesional · Argentina |
| 2022-04-30 | MainzvBayern MunichBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-04-30 | Dynamo MoscowvUralPremier League · Russia | 2–3 | Premier League · Russia |
| 2022-04-30 | ColchestervWalsallLeague Two · England | 2–2 | League Two · England |