| 2021-05-16 | St PaulivHannover2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-05-16 | LillevSt EtienneLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-05-16 | NurnbergvBochum2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-05-16 | BelenensesvSanta ClaraPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-05-16 | KarlsruhevHolstein Kiel2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-05-16 | SandhausenvRegensburg2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-05-16 | Real Salt LakevNashville SCMLS · United States | 0–0 | MLS · United States |
| 2021-05-16 | Paris SGvReimsLigue 1 · France | 4–0 | Ligue 1 · France |
| 2021-05-16 | SandefjordvMjondalenEliteserien · Norway | 0–3 | Eliteserien · Norway |
| 2021-05-16 | MoldevBrannEliteserien · Norway | 4–0 | Eliteserien · Norway |
| 2021-05-16 | LarisavGianninaSuper League · Greece | 2–0 | Super League · Greece |
| 2021-05-16 | LorientvMetzLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-05-16 | FeyenoordvWaalwijkEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2021-05-16 | MidtjyllandvRanders FCSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-05-16 | Cruz AzulvTolucaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-05-16 | SociedadvValladolidLa Liga · Spain | 4–1 | La Liga · Spain |
| 2021-05-16 | VikingvTromsoEliteserien · Norway | 0–1 | Eliteserien · Norway |
| 2021-05-16 | KhimkivSochiPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-05-16 | TambovvZenitPremier League · Russia | 1–5 | Premier League · Russia |
| 2021-05-16 | Lokomotiv MoscowvUralPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-05-16 | New England RevolutionvColumbus CrewMLS · United States | 1–0 | MLS · United States |
| 2021-05-16 | Philadelphia UnionvNew York Red BullsMLS · United States | 1–0 | MLS · United States |
| 2021-05-16 | MainzvDortmundBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2021-05-16 | DarmstadtvHeidenheim2. Bundesliga · Germany | 5–1 | 2. Bundesliga · Germany |
| 2021-05-16 | MilanvCagliariSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-05-16 | Gamba OsakavUrawa RedsJ1 League · Japan | 0–3 | J1 League · Japan |
| 2021-05-16 | LeganesvLogronesLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2021-05-16 | EvertonvSheffield UnitedPremier League · England | 0–1 | Premier League · England |
| 2021-05-16 | Colon Santa FEvTalleres CordobaCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-05-16 | MotherwellvRoss CountyPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-05-16 | Kawasaki FrontalevHokkaido Consadole SapporoJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-05-16 | CadizvElcheLa Liga · Spain | 1–3 | La Liga · Spain |
| 2021-05-15 | CaenvClermontLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-05-15 | Oita TrinitavSagan TosuJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-05-15 | AltachvRiedBundesliga · Austria | 3–0 | Bundesliga · Austria |
| 2021-05-15 | WeymouthvAltrinchamNational League · England | 2–1 | National League · England |
| 2021-05-15 | NiortvGuingampLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-05-15 | Sanfrecce HiroshimavTokushimaJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-05-15 | TrabzonsporvGenclerbirligiSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-05-15 | KayserisporvFenerbahceSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-05-15 | AntalyasporvKonyasporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-05-15 | BielefeldvHoffenheimBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-05-15 | SochauxvAuxerreLigue 2 · France | 2–3 | Ligue 2 · France |
| 2021-05-15 | New York CityvToronto FCMLS · United States | 1–1 | MLS · United States |
| 2021-05-15 | JuventusvInterSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-05-15 | ChesterfieldvWealdstoneNational League · England | 0–0 | National League · England |
| 2021-05-15 | MaidenheadvSuttonNational League · England | 0–3 | National League · England |
| 2021-05-15 | CastellonvPonferradinaLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-05-15 | AlmeriavAlbaceteLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-05-15 | Kashima AntlersvYokohama F. MarinosJ1 League · Japan | 5–3 | J1 League · Japan |