| 2022-05-02 | YeovilvWealdstoneNational League · England | 0–0 | National League · England |
| 2022-05-02 | Boreham WoodvWrexhamNational League · England | 1–1 | National League · England |
| 2022-05-02 | ChesterfieldvStockportNational League · England | 0–1 | National League · England |
| 2022-05-02 | LeverkusenvEin FrankfurtBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-05-02 | Arsenal TulavPari NNPremier League · Russia | 2–2 | Premier League · Russia |
| 2022-05-02 | Godoy CruzvCentral CordobaCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-05-02 | GoteborgvKalmarAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2022-05-02 | M'gladbachvRB LeipzigBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-05-02 | Port ValevNewport CountyLeague Two · England | 1–2 | League Two · England |
| 2022-05-02 | GetafevBetisLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-05-02 | SouthendvWeymouthNational League · England | 1–1 | National League · England |
| 2022-05-01 | CorinthiansvFortalezaSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2022-05-01 | Atl. San LuisvSantos LagunaLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2022-05-01 | Orlando CityvCharlotteMLS · United States | 2–1 | MLS · United States |
| 2022-05-01 | TroyesvLilleLigue 1 · France | 3–0 | Ligue 1 · France |
| 2022-05-01 | UdinesevInterSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-05-01 | VallecanovSociedadLa Liga · Spain | 1–1 | La Liga · Spain |
| 2022-05-01 | For SittardvFeyenoordEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2022-05-01 | EvertonvChelseaPremier League · England | 1–0 | Premier League · England |
| 2022-05-01 | MarseillevLyonLigue 1 · France | 0–3 | Ligue 1 · France |
| 2022-05-01 | HackenvVarbergAllsvenskan · Sweden | 3–1 | Allsvenskan · Sweden |
| 2022-05-01 | HeerenveenvCambuurEredivisie · Netherlands | 3–3 | Eredivisie · Netherlands |
| 2022-05-01 | BaselvZurichSuper League · Switzerland | 0–2 | Super League · Switzerland |
| 2022-05-01 | Nashville SCvPhiladelphia UnionMLS · United States | 1–1 | MLS · United States |
| 2022-05-01 |  MonacovAngersLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-05-01 | BarcelonavMallorcaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-05-01 | GuimaraesvSanta ClaraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-05-01 | WaalwijkvGroningenEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2022-05-01 | CoritibavFluminenseSerie A · Brazil | 3–2 | Serie A · Brazil |
| 2022-05-01 | SionvYoung BoysSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2022-05-01 | TottenhamvLeicesterPremier League · England | 3–1 | Premier League · England |
| 2022-05-01 | UNAM PumasvPachucaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-05-01 | JuventusvVeneziaSerie A · Italy | 2–1 | Serie A · Italy |
| 2022-05-01 | KhimkivUfaPremier League · Russia | 1–1 | Premier League · Russia |
| 2022-05-01 | New England RevolutionvInter MiamiMLS · United States | 2–0 | MLS · United States |
| 2022-05-01 | Spartak MoscowvKrylya SovetovPremier League · Russia | 2–1 | Premier League · Russia |
| 2022-05-01 | New York CityvSan Jose EarthquakesMLS · United States | 3–0 | MLS · United States |
| 2022-05-01 | Columbus CrewvDC UnitedMLS · United States | 3–0 | MLS · United States |
| 2022-05-01 | LanusvIndependienteCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-05-01 | PanathinaikosvArisSuper League · Greece | 1–0 | Super League · Greece |
| 2022-05-01 | GalatasarayvSivassporSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2022-05-01 | Termalica B-B.vWisla PlockEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2022-05-01 | MilanvFiorentinaSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-05-01 | GranadavCeltaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2022-05-01 | DegerforsvElfsborgAllsvenskan · Sweden | 0–6 | Allsvenskan · Sweden |
| 2022-05-01 | GoztepvRizesporSüper Lig · Turkey | 1–7 | Süper Lig · Turkey |
| 2022-05-01 | MontpelliervMetzLigue 1 · France | 2–2 | Ligue 1 · France |
| 2022-05-01 | Randers FCvBrondbySuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2022-05-01 | MjallbyvHelsingborgAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2022-05-01 | Sp GijonvIbizaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |