| 2021-05-16 | Colorado RapidsvHouston DynamoMLS · United States | 3–1 | MLS · United States |
| 2021-05-16 | NicevStrasbourgLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-05-16 | HammarbyvDjurgardenAllsvenskan · Sweden | 2–2 | Allsvenskan · Sweden |
| 2021-05-16 | Minnesota UnitedvFC DallasMLS · United States | 1–0 | MLS · United States |
| 2021-05-16 | Akhmat GroznyvSpartak MoscowPremier League · Russia | 2–2 | Premier League · Russia |
| 2021-05-16 | CracoviavWarta PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-05-16 | Atlanta UtdvCF MontrealMLS · United States | 1–0 | MLS · United States |
| 2021-05-16 | StockportvTorquayNational League · England | 2–2 | National League · England |
| 2021-05-16 | Crystal PalacevAston VillaPremier League · England | 3–2 | Premier League · England |
| 2021-05-16 | StromsgodsetvLillestromEliteserien · Norway | 3–1 | Eliteserien · Norway |
| 2021-05-16 | DijonvNantesLigue 1 · France | 0–4 | Ligue 1 · France |
| 2021-05-16 | TwentevDen HaagEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2021-05-16 | UdinesevSampdoriaSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-05-16 | Lech PoznanvGornik Z.Ekstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-05-16 | MaritimovGuimaraesPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-05-16 | MallorcavAlcorconLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-05-16 | FiorentinavNapoliSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-05-16 | Sporting Kansas CityvVancouver WhitecapsMLS · United States | 3–0 | MLS · United States |
| 2021-05-16 | Sepsi Sf. GheorghevFCSBSuperliga · Romania | 2–2 | Superliga · Romania |
| 2021-05-16 | Slask WroclawvStal MielecEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-05-16 | Fortuna DusseldorfvErzgebirge Aue2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-05-16 | Bodo/GlimtvRosenborgEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2021-05-16 | ParmavSassuoloSerie A · Italy | 1–3 | Serie A · Italy |
| 2021-05-16 | Pogon SzczecinvRakowEkstraklasa · Poland | 1–3 | Ekstraklasa · Poland |
| 2021-05-16 | MontpelliervBrestLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-05-16 | UTA AradvGaz Metan MediasSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-05-16 | UfavArsenal TulaPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-05-16 | FK RostovvKrasnodarPremier League · Russia | 1–3 | Premier League · Russia |
| 2021-05-16 | Ath BilbaovReal MadridLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-05-16 | ZwollevGroningenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-05-16 | St MirrenvDundee UnitedPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-05-16 | FC CopenhagenvBrondbySuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-05-16 | AarhusvNordsjaellandSuperliga · Denmark | 3–1 | Superliga · Denmark |
| 2021-05-16 | Rubin KazanvR. VolgogradPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-05-16 | HeerenveenvSparta RotterdamEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-05-16 | GetafevLevanteLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-05-16 | UtrechtvPSV EindhovenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-05-16 | Willem IIvFor SittardEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-05-16 | Wisla PlockvZaglebieEkstraklasa · Poland | 4–0 | Ekstraklasa · Poland |
| 2021-05-16 | SabadellvTenerifeLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-05-16 | VillarrealvSevillaLa Liga · Spain | 4–0 | La Liga · Spain |
| 2021-05-16 | BeneventovCrotoneSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-05-16 | Boca JuniorsvRiver PlateCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-05-16 | HamiltonvKilmarnockPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2021-05-16 | MarseillevAngersLigue 1 · France | 3–2 | Ligue 1 · France |
| 2021-05-16 | FamalicaovNacionalPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2021-05-16 | PanathinaikosvOlympiakosSuper League · Greece | 1–4 | Super League · Greece |
| 2021-05-16 | TirolvWolfsberger ACBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2021-05-16 | AZ AlkmaarvHeraclesEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2021-05-16 | PaderbornvGreuther Furth2. Bundesliga · Germany | 2–4 | 2. Bundesliga · Germany |