| 2010-01-16 | CagliarivLivornoSerie A · Italy | 3–0 | Serie A · Italy |
| 2010-01-16 | Man UnitedvBurnleyPremier League · England | 3–0 | Premier League · England |
| 2010-01-16 | BournemouthvBuryLeague Two · England | 1–2 | League Two · England |
| 2010-01-16 | LillevParis SGLigue 1 · France | 3–1 | Ligue 1 · France |
| 2010-01-16 | RegginavCesenaSerie B · Italy | 1–3 | Serie B · Italy |
| 2010-01-16 | MillwallvSouthamptonLeague One · England | 1–1 | League One · England |
| 2010-01-16 | WycombevCharltonLeague One · England | 1–2 | League One · England |
| 2010-01-16 | SwanseavLeicesterChampionship · England | 1–0 | Championship · England |
| 2010-01-16 | AhlenvSt Pauli2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2010-01-16 | Le MansvLorientLigue 1 · France | 0–3 | Ligue 1 · France |
| 2010-01-16 | BarnetvLincolnLeague Two · England | 1–2 | League Two · England |
| 2010-01-16 | BarivInterSerie A · Italy | 2–2 | Serie A · Italy |
| 2010-01-16 | PiacenzavEmpoliSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-01-16 |  Egyptv MozambiqueAfrican Cup of Nations | 2–0 | African Cup of Nations |
| 2010-01-16 | CharleroivGenkPro League · Belgium | 1–3 | Pro League · Belgium |
| 2010-01-16 | BurtonvShrewsburyLeague Two · England | 1–1 | League Two · England |
| 2010-01-16 | ChelseavSunderlandPremier League · England | 7–2 | Premier League · England |
| 2010-01-16 | HeartsvSt MirrenPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2010-01-16 | MontpelliervNiceLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-01-16 | MontrosevStranraerLeague Two · Scotland | 4–5 | League Two · Scotland |
| 2010-01-16 | Nott'm ForestvReadingChampionship · England | 2–1 | Championship · England |
| 2010-01-16 | TottenhamvHullPremier League · England | 0–0 | Premier League · England |
| 2010-01-16 | LeverkusenvMainzBundesliga · Germany | 4–2 | Bundesliga · Germany |
| 2010-01-16 | EbbsfleetvAltrinchamNational League · England | 1–2 | National League · England |
| 2010-01-16 | BetisvSalamancaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2010-01-16 | Sheffield UnitedvMiddlesbroughChampionship · England | 1–0 | Championship · England |
| 2010-01-16 | IstresvMetzLigue 2 · France | 2–2 | Ligue 2 · France |
| 2010-01-16 | Greuther FurthvKaiserslautern2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2010-01-16 | AngersvGuingampLigue 2 · France | 1–0 | Ligue 2 · France |
| 2010-01-16 | CeltavSociedadLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2010-01-16 | GrimsbyvCheltenhamLeague Two · England | 0–0 | League Two · England |
| 2010-01-16 | HartlepoolvMilton Keynes DonsLeague One · England | 0–5 | League One · England |
| 2010-01-16 | TriestinavMantovaSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-01-16 | CelticvFalkirkPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2010-01-16 | CittadellavBresciaSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-01-16 |  Nigeriav BeninAfrican Cup of Nations | 1–0 | African Cup of Nations |
| 2010-01-16 |  MonacovSochauxLigue 1 · France | 2–0 | Ligue 1 · France |
| 2010-01-16 | HamburgvFreiburgBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2010-01-16 | BrentfordvCarlisleLeague One · England | 3–1 | League One · England |
| 2010-01-16 | Queens ParkvBerwickLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2010-01-16 | Dag and RedvCreweLeague Two · England | 2–0 | League Two · England |
| 2010-01-16 | VicenzavAlbinoleffeSerie B · Italy | 1–2 | Serie B · Italy |
| 2010-01-16 | Las PalmasvMurciaLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2010-01-16 | PortovPacos FerreiraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-01-16 | PAOKvAsteras TripolisSuper League · Greece | 1–0 | Super League · Greece |
| 2010-01-16 | HannovervHerthaBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2010-01-16 | StuttgartvWolfsburgBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2010-01-16 | GallipolivAscoliSerie B · Italy | 1–4 | Serie B · Italy |
| 2010-01-16 | OsasunavEspanolLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-01-16 | M'gladbachvBochumBundesliga · Germany | 1–2 | Bundesliga · Germany |