| 2022-05-06 | Derry CityvBohemiansPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2022-05-06 | LevantevSociedadLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-05-06 | CosenzavCittadellaSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-05-06 | BeneventovSpalSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-05-06 | DroghedavSt. PatricksPremier Division · Ireland | 0–4 | Premier Division · Ireland |
| 2022-05-06 | GaziantepvKayserisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-05-06 | CrotonevParmaSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-05-06 | LeccevPordenoneSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-05-05 | FC CincinnativToronto FCMLS · United States | 2–0 | MLS · United States |
| 2022-05-05 | DjurgardenvHelsingborgAllsvenskan · Sweden | 2–2 | Allsvenskan · Sweden |
| 2022-05-05 | SalernitanavVeneziaSerie A · Italy | 2–1 | Serie A · Italy |
| 2022-05-04 | PAOKvOlympiakosSuper League · Greece | 1–2 | Super League · Greece |
| 2022-05-04 | KrasnodarvLokomotiv MoscowPremier League · Russia | 1–0 | Premier League · Russia |
| 2022-05-04 | Gamba OsakavHokkaido Consadole SapporoJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-05-03 | Kashima AntlersvIwataJ1 League · Japan | 3–1 | J1 League · Japan |
| 2022-05-03 | Sagan TosuvCerezo OsakaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-05-03 | HuracanvRosario CentralCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-05-03 | PlatensevArgentinos JrsCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-05-03 | Shonan BellmarevShimizu S-PulseJ1 League · Japan | 1–4 | J1 League · Japan |
| 2022-05-03 | Avispa FukuokavFC TokyoJ1 League · Japan | 5–1 | J1 League · Japan |
| 2022-05-03 | Nagoya GrampusvKyotoJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-05-03 | Sanfrecce HiroshimavKashiwa ReysolJ1 League · Japan | 1–2 | J1 League · Japan |
| 2022-05-03 | BournemouthvNott'm ForestChampionship · England | 1–0 | Championship · England |
| 2022-05-03 | Inter TurkuvHJKVeikkausliiga · Finland | 0–1 | Veikkausliiga · Finland |
| 2022-05-03 | Sao PaulovSantosSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2022-05-02 | ValladolidvSociedad BLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2022-05-02 | EastleighvHalifaxNational League · England | 1–2 | National League · England |
| 2022-05-02 | MaidenheadvAldershotNational League · England | 2–2 | National League · England |
| 2022-05-02 | AltrinchamvBarnetNational League · England | 1–1 | National League · England |
| 2022-05-02 | Union de Santa FevDefensa y JusticiaCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-05-02 | SolihullvBromleyNational League · England | 3–0 | National League · England |
| 2022-05-02 | RodezvToulouseLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-05-02 | IonikosvApollonSuper League · Greece | 5–1 | Super League · Greece |
| 2022-05-02 | SalfordvMansfieldLeague Two · England | 2–2 | League Two · England |
| 2022-05-02 | WokingvKings LynnNational League · England | 0–3 | National League · England |
| 2022-05-02 | FulhamvLutonChampionship · England | 7–0 | Championship · England |
| 2022-05-02 | Pacos FerreiravTondelaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-05-02 | Los Angeles FCvMinnesota UnitedMLS · United States | 2–0 | MLS · United States |
| 2022-05-02 | Notts CountyvDover AthleticNational League · England | 1–0 | National League · England |
| 2022-05-02 | MiovenivFC BotosaniSuperliga · Romania | 0–2 | Superliga · Romania |
| 2022-05-02 | Dag and RedvTorquayNational League · England | 0–0 | National League · England |
| 2022-05-02 | FCSBvFC ArgesSuperliga · Romania | 4–0 | Superliga · Romania |
| 2022-05-02 | SilkeborgvAalborgSuperliga · Denmark | 4–2 | Superliga · Denmark |
| 2022-05-02 | HammarbyvMalmo FFAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2022-05-02 | AtalantavSalernitanaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-05-02 | Club LeonvTolucaLiga MX · Mexico | 4–4 | Liga MX · Mexico |
| 2022-05-02 | Man UnitedvBrentfordPremier League · England | 3–0 | Premier League · England |
| 2022-05-02 | LeganesvHuescaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-05-02 | NorrkopingvVarnamoAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2022-05-02 | Asteras TripolisvLamiaSuper League · Greece | 0–2 | Super League · Greece |