| 2021-05-17 | OstersundsvAIKAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-05-17 | Club AmericavPachucaLiga MX · Mexico | 4–2 | Liga MX · Mexico |
| 2021-05-17 | MjallbyvHackenAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-05-17 | MonterreyvSantos LagunaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-05-17 | HJKvLahtiVeikkausliiga · Finland | 2–0 | Veikkausliiga · Finland |
| 2021-05-17 | DC UnitedvOrlando CityMLS · United States | 0–1 | MLS · United States |
| 2021-05-17 | Malmo FFvKalmarAllsvenskan · Sweden | 3–1 | Allsvenskan · Sweden |
| 2021-05-17 | SonderjyskevLyngbySuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-05-17 | Changchun YataivShanghai ShenhuaSuper League · China | 1–0 | Super League · China |
| 2021-05-17 | Tianjin Jinmen TigervWuhan FCSuper League · China | 2–1 | Super League · China |
| 2021-05-17 | OviedovMalagaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-05-17 | VarbergvNorrkopingAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2021-05-17 | GironavSp GijonLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-05-17 | VeronavBolognaSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-05-17 | Seattle SoundersvLos Angeles FCMLS · United States | 2–0 | MLS · United States |
| 2021-05-17 | GoteborgvSiriusAllsvenskan · Sweden | 2–2 | Allsvenskan · Sweden |
| 2021-05-17 | ElfsborgvHalmstadAllsvenskan · Sweden | 2–3 | Allsvenskan · Sweden |
| 2021-05-16 | RB LeipzigvWolfsburgBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-05-16 | Velez SarsfieldvRacing ClubCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2021-05-16 | Dynamo MoscowvCSKA MoscowPremier League · Russia | 3–2 | Premier League · Russia |
| 2021-05-16 | PueblavAtlasLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-05-16 | LegiavPodbeskidzieEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-05-16 | Sturm GrazvSK RapidBundesliga · Austria | 4–1 | Bundesliga · Austria |
| 2021-05-16 | AlavesvGranadaLa Liga · Spain | 4–2 | La Liga · Spain |
| 2021-05-16 | VitessevAjaxEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-05-16 | Piast GliwicevWislaEkstraklasa · Poland | 2–3 | Ekstraklasa · Poland |
| 2021-05-16 | AalborgvHorsensSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-05-16 | ValenciavEibarLa Liga · Spain | 4–1 | La Liga · Spain |
| 2021-05-16 | LASKvSalzburgBundesliga · Austria | 2–5 | Bundesliga · Austria |
| 2021-05-16 | JagielloniavLechia GdanskEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-05-16 | BarcelonavCeltaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-05-16 | BordeauxvLensLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-05-16 | FC CincinnativInter MiamiMLS · United States | 2–3 | MLS · United States |
| 2021-05-16 | Sarpsborg 08vHaugesundEliteserien · Norway | 0–0 | Eliteserien · Norway |
| 2021-05-16 | TottenhamvWolvesPremier League · England | 2–0 | Premier League · England |
| 2021-05-16 | San Jose EarthquakesvPortland TimbersMLS · United States | 0–2 | MLS · United States |
| 2021-05-16 | BetisvHuescaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-05-16 | FuenlabradavVallecanoLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-05-16 | OsnabruckvHamburg2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-05-16 | ValerengavKristiansundEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2021-05-16 | FC ArgesvDin. BucurestiSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-05-16 | VVV VenlovFC EmmenEredivisie · Netherlands | 0–4 | Eredivisie · Netherlands |
| 2021-05-16 | West BromvLiverpoolPremier League · England | 1–2 | Premier League · England |
| 2021-05-16 | AEKvArisSuper League · Greece | 0–0 | Super League · Greece |
| 2021-05-16 |  MonacovRennesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-05-16 | Shanghai PortvDalian ProSuper League · China | 3–0 | Super League · China |
| 2021-05-16 | NimesvLyonLigue 1 · France | 2–5 | Ligue 1 · France |
| 2021-05-16 | PAOKvAsteras TripolisSuper League · Greece | 0–1 | Super League · Greece |
| 2021-05-16 | BraunschweigvWurzburger Kickers2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-05-16 | Ath MadridvOsasunaLa Liga · Spain | 2–1 | La Liga · Spain |