| 2022-05-07 | CelticvHeartsPremiership · Scotland | 4–1 | Premiership · Scotland |
| 2022-05-07 | Cruz AzulvNecaxaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-05-07 | YeovilvBoreham WoodNational League · England | 2–2 | National League · England |
| 2022-05-07 | PanetolikosvVolos NFCSuper League · Greece | 0–0 | Super League · Greece |
| 2022-05-07 | PrestonvMiddlesbroughChampionship · England | 4–1 | Championship · England |
| 2022-05-07 | Pau FCvNiortLigue 2 · France | 2–2 | Ligue 2 · France |
| 2022-05-07 | CeltavAlavesLa Liga · Spain | 4–0 | La Liga · Spain |
| 2022-05-07 | Malmo FFvMjallbyAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2022-05-07 | Ross CountyvMotherwellPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2022-05-07 | BrestvStrasbourgLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-05-07 | PonferradinavBurgosLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2022-05-07 | BrentfordvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2022-05-07 | WealdstonevKings LynnNational League · England | 2–1 | National League · England |
| 2022-05-07 | WeymouthvBarnetNational League · England | 1–2 | National League · England |
| 2022-05-07 | ApollonvLamiaSuper League · Greece | 0–0 | Super League · Greece |
| 2022-05-07 | Ath BilbaovValenciaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-05-07 | HakavVPSVeikkausliiga · Finland | 0–2 | Veikkausliiga · Finland |
| 2022-05-07 | UTA AradvMioveniSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-05-07 | Sarpsborg 08vOddEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2022-05-07 | WokingvEastleighNational League · England | 1–2 | National League · England |
| 2022-05-07 | GrimsbyvMaidenheadNational League · England | 1–3 | National League · England |
| 2022-05-07 | LivingstonvSt JohnstonePremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-05-07 | AdmiravTirolBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2022-05-06 | PaderbornvSandhausen2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-05-06 | San LorenzovRacing ClubCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-05-06 | BresciavRegginaSerie B · Italy | 3–0 | Serie B · Italy |
| 2022-05-06 | Lillev MonacoLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-05-06 | Fortuna DusseldorfvDarmstadt2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-05-06 | Las PalmasvMirandesLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-05-06 | GenoavJuventusSerie A · Italy | 2–1 | Serie A · Italy |
| 2022-05-06 | AscolivTernanaSerie B · Italy | 4–1 | Serie B · Italy |
| 2022-05-06 | HataysporvTrabzonsporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-05-06 | SilkeborgvRanders FCSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2022-05-06 | Radomiak RadomvZaglebieEkstraklasa · Poland | 1–6 | Ekstraklasa · Poland |
| 2022-05-06 | LegiavGornik Z.Ekstraklasa · Poland | 5–3 | Ekstraklasa · Poland |
| 2022-05-06 | IntervEmpoliSerie A · Italy | 4–2 | Serie A · Italy |
| 2022-05-06 | AlessandriavVicenzaSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-05-06 | BochumvBielefeldBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-05-06 | ComovCremoneseSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-05-06 | FC BotosanivDin. BucurestiSuperliga · Romania | 2–3 | Superliga · Romania |
| 2022-05-06 | BoavistavGuimaraesPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-05-06 | Shamrock RoversvFinn HarpsPremier Division · Ireland | 3–1 | Premier Division · Ireland |
| 2022-05-06 | Krylya SovetovvDynamo MoscowPremier League · Russia | 5–2 | Premier League · Russia |
| 2022-05-06 | UC DublinvDundalkPremier Division · Ireland | 2–2 | Premier Division · Ireland |
| 2022-05-06 | ShelbournevSligo RoversPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2022-05-06 | Gaz Metan MediasvAcademica ClinceniSuperliga · Romania | 4–3 | Superliga · Romania |
| 2022-05-06 | CambuurvWaalwijkEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-05-06 | Cerezo OsakavIwataJ1 League · Japan | 2–1 | J1 League · Japan |
| 2022-05-06 | PerugiavMonzaSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-05-06 | FrosinonevPisaSerie B · Italy | 1–2 | Serie B · Italy |