| 2021-05-20 | PachucavCruz AzulLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-05-20 | Malmo FFvElfsborgAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2021-05-20 | AarhusvBrondbySuperliga · Denmark | 1–2 | Superliga · Denmark |
| 2021-05-20 | HorsensvSonderjyskeSuperliga · Denmark | 1–2 | Superliga · Denmark |
| 2021-05-20 | Academica ClincenivSepsi Sf. GheorgheSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-05-19 | StabaekvOddEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2021-05-19 | NewcastlevSheffield UnitedPremier League · England | 1–0 | Premier League · England |
| 2021-05-19 | FCSBvUniv. CraiovaSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-05-19 | Crystal PalacevArsenalPremier League · England | 1–3 | Premier League · England |
| 2021-05-19 | GuimaraesvBenficaPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2021-05-19 | Sp LisbonvMaritimoPrimeira Liga · Portugal | 5–1 | Primeira Liga · Portugal |
| 2021-05-19 | AalborgvVejleSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-05-19 | FC HermannstadtvFC ArgesSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-05-19 | NacionalvRio AvePrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-05-19 | Santa ClaravFarensePrimeira Liga · Portugal | 4–0 | Primeira Liga · Portugal |
| 2021-05-19 | FC CopenhagenvMidtjyllandSuperliga · Denmark | 4–2 | Superliga · Denmark |
| 2021-05-19 | TenerifevMallorcaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-05-19 | MoreirensevFamalicaoPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2021-05-19 | Din. BucurestivChindia TargovisteSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-05-19 | FC VoluntarivUTA AradSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-05-19 | PortovBelenensesPrimeira Liga · Portugal | 4–0 | Primeira Liga · Portugal |
| 2021-05-19 | West BromvWest HamPremier League · England | 1–3 | Premier League · England |
| 2021-05-19 | MirandesvLeganesLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-05-19 | GianninavApollonSuper League · Greece | 0–2 | Super League · Greece |
| 2021-05-19 | EvertonvWolvesPremier League · England | 1–0 | Premier League · England |
| 2021-05-19 | TottenhamvAston VillaPremier League · England | 1–2 | Premier League · England |
| 2021-05-19 | Gaz Metan MediasvPoli IasiSuperliga · Romania | 4–2 | Superliga · Romania |
| 2021-05-19 | NordsjaellandvRanders FCSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-05-19 | BurnleyvLiverpoolPremier League · England | 0–3 | Premier League · England |
| 2021-05-19 | AlcorconvSabadellLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-05-19 | LogronesvFuenlabradaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-05-19 | Gil VicentevBoavistaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-05-19 | Viitorul ConstantavAstraSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-05-19 | PortimonensevSp BragaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-05-19 | SolihullvBarnetNational League · England | 1–0 | National League · England |
| 2021-05-18 | TondelavPacos FerreiraPrimeira Liga · Portugal | 2–3 | Primeira Liga · Portugal |
| 2021-05-18 | SouthamptonvLeedsPremier League · England | 0–2 | Premier League · England |
| 2021-05-18 | LaziovTorinoSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-05-18 | AlbacetevLugoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-05-18 | WrexhamvNotts CountyNational League · England | 0–1 | National League · England |
| 2021-05-18 | Man UnitedvFulhamPremier League · England | 1–1 | Premier League · England |
| 2021-05-18 | WeymouthvBoreham WoodNational League · England | 1–3 | National League · England |
| 2021-05-18 | AldershotvEastleighNational League · England | 1–3 | National League · England |
| 2021-05-18 | DegerforsvOrebroAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2021-05-18 | PonferradinavEspanolLa Liga 2 · Spain | 1–4 | La Liga 2 · Spain |
| 2021-05-18 | FC BotosanivCFR ClujSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-05-18 | BrightonvMan CityPremier League · England | 3–2 | Premier League · England |
| 2021-05-18 | YeovilvMaidenheadNational League · England | 0–0 | National League · England |
| 2021-05-18 | ChelseavLeicesterPremier League · England | 2–1 | Premier League · England |
| 2021-05-18 | CartagenavAlmeriaLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |