| 2022-05-07 | LaziovSampdoriaSerie A · Italy | 2–0 | Serie A · Italy |
| 2022-05-07 | BrightonvMan UnitedPremier League · England | 4–0 | Premier League · England |
| 2022-05-07 | CF MontrealvOrlando CityMLS · United States | 4–1 | MLS · United States |
| 2022-05-07 | CharlottevInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2022-05-07 | Yokohama F. MarinosvNagoya GrampusJ1 League · Japan | 2–1 | J1 League · Japan |
| 2022-05-07 | SJKvLahtiVeikkausliiga · Finland | 1–2 | Veikkausliiga · Finland |
| 2022-05-07 | HalifaxvAldershotNational League · England | 1–1 | National League · England |
| 2022-05-07 | Ad. DemirsporvAlanyasporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2022-05-07 | LASKvHartbergBundesliga · Austria | 3–3 | Bundesliga · Austria |
| 2022-05-07 | BirminghamvBlackburnChampionship · England | 1–2 | Championship · England |
| 2022-05-07 | MalagavOviedoLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-05-07 | BuyuksehyrvGalatasaraySüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2022-05-07 | Crystal PalacevWatfordPremier League · England | 1–0 | Premier League · England |
| 2022-05-07 | RegensburgvHeidenheim2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2022-05-07 | TorquayvChesterfieldNational League · England | 2–0 | National League · England |
| 2022-05-07 | West BromvBarnsleyChampionship · England | 4–0 | Championship · England |
| 2022-05-07 | HonkavInter TurkuVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2022-05-07 | OldhamvCrawley TownLeague Two · England | 3–3 | League Two · England |
| 2022-05-07 | WalsallvSwindonLeague Two · England | 0–3 | League Two · England |
| 2022-05-07 | WislavJagielloniaEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2022-05-07 | IndependientevHuracanCopa De La Liga Profesional · Argentina | 3–0 | Copa De La Liga Profesional · Argentina |
| 2022-05-07 | BradfordvCarlisleLeague Two · England | 2–0 | League Two · England |
| 2022-05-07 | AmiensvParis FCLigue 2 · France | 1–2 | Ligue 2 · France |
| 2022-05-07 | Newport CountyvRochdaleLeague Two · England | 0–2 | League Two · England |
| 2022-05-07 | AC OuluvHIFKVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2022-05-07 | Bristol RvsvScunthorpeLeague Two · England | 7–0 | League Two · England |
| 2022-05-07 | Slask WroclawvPogon SzczecinEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-05-07 | FC KolnvWolfsburgBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2022-05-07 | CSKA MoscowvSochiPremier League · Russia | 0–1 | Premier League · Russia |
| 2022-05-07 | HerthavMainzBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-05-07 | ZwollevUtrechtEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-05-07 | HullvNott'm ForestChampionship · England | 1–1 | Championship · England |
| 2022-05-07 | HoffenheimvLeverkusenBundesliga · Germany | 2–4 | Bundesliga · Germany |
| 2022-05-07 | PortimonensevSp LisbonPrimeira Liga · Portugal | 2–3 | Primeira Liga · Portugal |
| 2022-05-07 | DerbyvCardiffChampionship · England | 0–1 | Championship · England |
| 2022-05-07 | StokevCoventryChampionship · England | 1–1 | Championship · England |
| 2022-05-07 | GrenoblevAjaccioLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-05-07 | BarrowvNorthamptonLeague Two · England | 1–3 | League Two · England |
| 2022-05-07 | TigrevBoca JuniorsCopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2022-05-07 | IngolstadtvHansa Rostock2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2022-05-07 | St MirrenvDundeePremiership · Scotland | 2–0 | Premiership · Scotland |
| 2022-05-07 | BromleyvDover AthleticNational League · England | 2–2 | National League · England |
| 2022-05-07 | BetisvBarcelonaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2022-05-07 | Pari NNvAkhmat GroznyPremier League · Russia | 0–1 | Premier League · Russia |
| 2022-05-07 | AIKvGoteborgAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2022-05-07 | StevenagevSalfordLeague Two · England | 4–2 | League Two · England |
| 2022-05-07 | Willem IIvHeraclesEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2022-05-07 | Le HavrevAuxerreLigue 2 · France | 1–2 | Ligue 2 · France |
| 2022-05-07 | ExetervPort ValeLeague Two · England | 0–1 | League Two · England |
| 2022-05-07 | DunkerquevGuingampLigue 2 · France | 1–3 | Ligue 2 · France |