| 2021-05-22 | Urawa RedsvVissel KobeJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-05-22 | ValladolidvAth MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-05-22 | WrexhamvKings LynnNational League · England | 5–3 | National League · England |
| 2021-05-22 | Avispa FukuokavShonan BellmareJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-05-22 | TorquayvBarnetNational League · England | 2–2 | National League · England |
| 2021-05-22 | Portland TimbersvLos Angeles GalaxyMLS · United States | 3–0 | MLS · United States |
| 2021-05-22 | Hokkaido Consadole SapporovShimizu S-PulseJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-05-22 | Ein FrankfurtvFreiburgBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-05-22 | Chicago FirevInter MiamiMLS · United States | 1–0 | MLS · United States |
| 2021-05-22 | CeltavBetisLa Liga · Spain | 2–3 | La Liga · Spain |
| 2021-05-22 | StockportvWokingNational League · England | 1–1 | National League · England |
| 2021-05-22 | Sagan TosuvKashima AntlersJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-05-22 | LahtivHonkaVeikkausliiga · Finland | 1–0 | Veikkausliiga · Finland |
| 2021-05-22 | FC TokyovGamba OsakaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-05-22 | EibarvBarcelonaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-05-22 | HoffenheimvHerthaBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-05-22 | DortmundvLeverkusenBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-05-22 | MaidenheadvHalifaxNational League · England | 1–2 | National League · England |
| 2021-05-22 | Inter TurkuvKTPVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2021-05-22 | TokushimavNagoya GrampusJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-05-22 | SJKvHJKVeikkausliiga · Finland | 0–2 | Veikkausliiga · Finland |
| 2021-05-22 | CagliarivGenoaSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-05-22 | SK RapidvLASKBundesliga · Austria | 3–0 | Bundesliga · Austria |
| 2021-05-22 | EastleighvBoreham WoodNational League · England | 1–0 | National League · England |
| 2021-05-22 | CF MontrealvFC CincinnatiMLS · United States | 1–2 | MLS · United States |
| 2021-05-22 | AldershotvBromleyNational League · England | 2–3 | National League · England |
| 2021-05-22 | Wolfsberger ACvSturm GrazBundesliga · Austria | 1–3 | Bundesliga · Austria |
| 2021-05-22 | IlvesvKuPSVeikkausliiga · Finland | 3–2 | Veikkausliiga · Finland |
| 2021-05-22 | AltrinchamvYeovilNational League · England | 4–3 | National League · England |
| 2021-05-21 | DundalkvShamrock RoversPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-05-21 | ZurichvVaduzSuper League · Switzerland | 4–1 | Super League · Switzerland |
| 2021-05-21 | LuzernvLuganoSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2021-05-21 | Santos LagunavPueblaLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2021-05-21 | RiedvAustria ViennaBundesliga · Austria | 3–2 | Bundesliga · Austria |
| 2021-05-21 | LausannevYoung BoysSuper League · Switzerland | 2–4 | Super League · Switzerland |
| 2021-05-21 | AdmiravAltachBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-05-21 | SionvBaselSuper League · Switzerland | 4–0 | Super League · Switzerland |
| 2021-05-21 | Sligo RoversvLongfordPremier Division · Ireland | 2–0 | Premier Division · Ireland |
| 2021-05-21 | Finn HarpsvDroghedaPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-05-21 | St. PoltenvHartbergBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-05-21 | WaterfordvDerry CityPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-05-21 | ServettevSt. GallenSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2021-05-21 | LevantevCadizLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-05-21 | St. PatricksvBohemiansPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-05-20 | RosenborgvBrannEliteserien · Norway | 3–2 | Eliteserien · Norway |
| 2021-05-20 | LyngbyvOdenseSuperliga · Denmark | 1–2 | Superliga · Denmark |
| 2021-05-20 | Sp GijonvLas PalmasLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-05-20 | MalagavGironaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-05-20 | ZaragozavCastellonLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2021-05-20 | VallecanovOviedoLa Liga 2 · Spain | 4–1 | La Liga 2 · Spain |