| 2022-05-07 | AtromitosvIonikosSuper League · Greece | 0–1 | Super League · Greece |
| 2022-05-07 | ToulousevNimesLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-05-07 | Leyton OrientvTranmereLeague Two · England | 0–1 | League Two · England |
| 2022-05-07 | AlmeriavAmorebietaLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2022-05-07 | KaragumrukvGoztepSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2022-05-07 | ZenitvKhimkiPremier League · Russia | 1–0 | Premier League · Russia |
| 2022-05-07 | HuddersfieldvBristol CityChampionship · England | 2–0 | Championship · England |
| 2022-05-07 | AldosivivArsenal SarandiCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-05-07 | HuescavSp GijonLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-05-07 | LutonvReadingChampionship · England | 1–0 | Championship · England |
| 2022-05-07 | Atletico-MGvAmerica MGSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2022-05-07 | LiverpoolvTottenhamPremier League · England | 1–1 | Premier League · England |
| 2022-05-07 | GroningenvSparta RotterdamEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-05-07 | MoldevVikingEliteserien · Norway | 3–4 | Eliteserien · Norway |
| 2022-05-07 | Wisla PlockvWarta PoznanEkstraklasa · Poland | 0–3 | Ekstraklasa · Poland |
| 2022-05-07 | MallorcavGranadaLa Liga · Spain | 2–6 | La Liga · Spain |
| 2022-05-07 | BournemouthvMillwallChampionship · England | 1–0 | Championship · England |
| 2022-05-07 | SivassporvKasimpasaSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2022-05-07 | LuganovYoung BoysSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2022-05-07 | Farul ConstantavFC VoluntariSuperliga · Romania | 1–1 | Superliga · Romania |
| 2022-05-07 | HarrogatevSuttonLeague Two · England | 0–2 | League Two · England |
| 2022-05-07 | FuenlabradavSociedad BLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2022-05-07 | Rosario CentralvEstudiantes L.P.Copa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2022-05-07 | BurnleyvAston VillaPremier League · England | 1–3 | Premier League · England |
| 2022-05-07 | PeterborovBlackpoolChampionship · England | 5–0 | Championship · England |
| 2022-05-07 | St. GallenvZurichSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2022-05-07 | CaenvQuevilly RouenLigue 2 · France | 2–0 | Ligue 2 · France |
| 2022-05-07 | Notts CountyvAltrinchamNational League · England | 3–0 | National League · England |
| 2022-05-07 | ValenciennesvSochauxLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-05-07 | HibernianvAberdeenPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-05-07 | TorinovNapoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2022-05-07 | FC ArgesvCFR ClujSuperliga · Romania | 0–6 | Superliga · Romania |
| 2022-05-07 | Avispa FukuokavShonan BellmareJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-05-07 | Sheffield UnitedvFulhamChampionship · England | 4–0 | Championship · England |
| 2022-05-07 | Sanfrecce HiroshimavKashima AntlersJ1 League · Japan | 3–0 | J1 League · Japan |
| 2022-05-07 | FreiburgvUnion BerlinBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2022-05-07 | AltachvRiedBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2022-05-07 | DijonvNancyLigue 2 · France | 2–3 | Ligue 2 · France |
| 2022-05-07 | Barracas CentralvGodoy CruzCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2022-05-07 | Shimizu S-PulsevKawasaki FrontaleJ1 League · Japan | 0–2 | J1 League · Japan |
| 2022-05-07 | BenficavPortoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-05-07 | Atlanta UtdvChicago FireMLS · United States | 4–1 | MLS · United States |
| 2022-05-07 | Greuther FurthvDortmundBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2022-05-07 | CadizvElcheLa Liga · Spain | 3–0 | La Liga · Spain |
| 2022-05-07 | MansfieldvForest GreenLeague Two · England | 2–2 | League Two · England |
| 2022-05-07 | TwentevFor SittardEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-05-07 | HamburgvHannover2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-05-07 | EstorilvMoreirensePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2022-05-07 | SolihullvDag and RedNational League · England | 3–1 | National League · England |
| 2022-05-07 | BastiavRodezLigue 2 · France | 0–1 | Ligue 2 · France |