| 2021-05-23 | Cruz AzulvPachucaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-05-23 | LyonvNiceLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-05-23 | GranadavGetafeLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-05-23 | BolognavJuventusSerie A · Italy | 1–4 | Serie A · Italy |
| 2021-05-23 | LeedsvWest BromPremier League · England | 3–1 | Premier League · England |
| 2021-05-23 | Houston DynamovVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2021-05-23 | IntervUdineseSerie A · Italy | 5–1 | Serie A · Italy |
| 2021-05-23 | Orlando CityvToronto FCMLS · United States | 1–0 | MLS · United States |
| 2021-05-23 | MetzvMarseilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-05-23 | HannovervNurnberg2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-05-23 | RegensburgvSt Pauli2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-05-23 | KalmarvHammarbyAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2021-05-23 | SuttonvHartlepoolNational League · England | 3–0 | National League · England |
| 2021-05-23 | WolvesvMan UnitedPremier League · England | 1–2 | Premier League · England |
| 2021-05-23 | EspanolvTenerifeLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-05-23 | Man CityvEvertonPremier League · England | 5–0 | Premier League · England |
| 2021-05-23 | Seattle SoundersvAtlanta UtdMLS · United States | 1–1 | MLS · United States |
| 2021-05-23 | AngersvLilleLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-05-23 | Sheffield UnitedvBurnleyPremier League · England | 1–0 | Premier League · England |
| 2021-05-23 | LiverpoolvCrystal PalacePremier League · England | 2–0 | Premier League · England |
| 2021-05-23 | DjurgardenvGoteborgAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-05-23 | Wurzburger KickersvPaderborn2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-05-23 | SpeziavRomaSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-05-23 | Greuther FurthvFortuna Dusseldorf2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-05-23 | SevillavAlavesLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-05-23 | New York CityvColumbus CrewMLS · United States | 1–2 | MLS · United States |
| 2021-05-23 | Aston VillavChelseaPremier League · England | 2–1 | Premier League · England |
| 2021-05-23 | Cerezo OsakavSanfrecce HiroshimaJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-05-23 |  Ukrainev BahrainFriendly | 1–1 | Friendly |
| 2021-05-22 | Real MadridvVillarrealLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-05-22 | Yokohama F. MarinosvKashiwa ReysolJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-05-22 | ChesterfieldvDag and RedNational League · England | 2–1 | National League · England |
| 2021-05-22 | OstersundsvSiriusAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2021-05-22 | Vegalta SendaivOita TrinitaJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-05-22 | Union BerlinvRB LeipzigBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-05-22 | AIKvMjallbyAllsvenskan · Sweden | 2–2 | Allsvenskan · Sweden |
| 2021-05-22 | ElchevAth BilbaoLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-05-22 | StuttgartvBielefeldBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2021-05-22 | FC KolnvSchalke 04Bundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-05-22 | CrotonevFiorentinaSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-05-22 | WealdstonevSolihullNational League · England | 1–4 | National League · England |
| 2021-05-22 | Bayern MunichvAugsburgBundesliga · Germany | 5–2 | Bundesliga · Germany |
| 2021-05-22 | Werder BremenvM'gladbachBundesliga · Germany | 2–4 | Bundesliga · Germany |
| 2021-05-22 | Kawasaki FrontalevYokohama FCJ1 League · Japan | 3–1 | J1 League · Japan |
| 2021-05-22 | OsasunavSociedadLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-05-22 | SampdoriavParmaSerie A · Italy | 3–0 | Serie A · Italy |
| 2021-05-22 | HuescavValenciaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-05-22 | Notts CountyvWeymouthNational League · England | 3–0 | National League · England |
| 2021-05-22 | WolfsburgvMainzBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2021-05-22 | SalzburgvTirolBundesliga · Austria | 4–0 | Bundesliga · Austria |