| 2021-05-24 | OviedovMirandesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-05-24 | DroghedavLongfordPremier Division · Ireland | 4–1 | Premier Division · Ireland |
| 2021-05-24 | WaterfordvFinn HarpsPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2021-05-24 | OdensevHorsensSuperliga · Denmark | 4–0 | Superliga · Denmark |
| 2021-05-24 | LugovCartagenaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-05-24 | DC UnitedvPhiladelphia UnionMLS · United States | 0–1 | MLS · United States |
| 2021-05-24 | LillestromvVikingEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2021-05-24 | GironavAlcorconLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-05-24 | Shamrock RoversvSligo RoversPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-05-24 | OrebrovMalmo FFAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-05-24 | CastellonvVallecanoLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-05-24 | VejlevLyngbySuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-05-24 | BohemiansvDundalkPremier Division · Ireland | 5–1 | Premier Division · Ireland |
| 2021-05-24 | Randers FCvFC CopenhagenSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-05-24 | HartbergvAustria ViennaBundesliga · Austria | 0–3 | Bundesliga · Austria |
| 2021-05-24 | PueblavSantos LagunaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-05-24 | SonderjyskevAalborgSuperliga · Denmark | 0–4 | Superliga · Denmark |
| 2021-05-24 | KristiansundvStromsgodsetEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2021-05-24 | SabadellvPonferradinaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-05-24 | LeganesvMalagaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-05-24 | TromsovSandefjordEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2021-05-23 | RennesvNimesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-05-23 | San Jose EarthquakesvSporting Kansas CityMLS · United States | 1–3 | MLS · United States |
| 2021-05-23 | St EtiennevDijonLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-05-23 | ArsenalvBrightonPremier League · England | 2–0 | Premier League · England |
| 2021-05-23 | AC OuluvHIFKVeikkausliiga · Finland | 1–2 | Veikkausliiga · Finland |
| 2021-05-23 | FulhamvNewcastlePremier League · England | 0–2 | Premier League · England |
| 2021-05-23 | MariehamnvHakaVeikkausliiga · Finland | 0–3 | Veikkausliiga · Finland |
| 2021-05-23 | TorinovBeneventoSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-05-23 | HalmstadvDegerforsAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-05-23 | StrasbourgvLorientLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-05-23 | FC DallasvReal Salt LakeMLS · United States | 2–2 | MLS · United States |
| 2021-05-23 | HamburgvBraunschweig2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2021-05-23 | SassuolovLazioSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-05-23 | AtalantavMilanSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-05-23 | Lensv MonacoLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-05-23 | New England RevolutionvNew York Red BullsMLS · United States | 3–1 | MLS · United States |
| 2021-05-23 | LeicestervTottenhamPremier League · England | 2–4 | Premier League · England |
| 2021-05-23 | BochumvSandhausen2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-05-23 | HeidenheimvKarlsruhe2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-05-23 | NantesvMontpellierLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-05-23 | NapolivVeronaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-05-23 | Erzgebirge AuevOsnabruck2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-05-23 | Los Angeles FCvColorado RapidsMLS · United States | 2–1 | MLS · United States |
| 2021-05-23 | Holstein KielvDarmstadt2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2021-05-23 | BrestvParis SGLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-05-23 | HackenvVarbergAllsvenskan · Sweden | 3–1 | Allsvenskan · Sweden |
| 2021-05-23 | ReimsvBordeauxLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-05-23 | West HamvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2021-05-23 | MallorcavZaragozaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |