| 2022-05-08 | Ein FrankfurtvM'gladbachBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-05-08 | Minnesota UnitedvFC CincinnatiMLS · United States | 0–1 | MLS · United States |
| 2022-05-08 | LuzernvServetteSuper League · Switzerland | 4–0 | Super League · Switzerland |
| 2022-05-08 | MetzvLyonLigue 1 · France | 3–2 | Ligue 1 · France |
| 2022-05-08 | AarhusvSonderjyskeSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2022-05-08 | VeneziavBolognaSerie A · Italy | 4–3 | Serie A · Italy |
| 2022-05-08 | NordsjaellandvOdenseSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2022-05-08 | GetafevVallecanoLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-05-08 | HaugesundvKristiansundEliteserien · Norway | 2–0 | Eliteserien · Norway |
| 2022-05-08 | SandefjordvValerengaEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2022-05-08 | VeronavMilanSerie A · Italy | 1–3 | Serie A · Italy |
| 2022-05-08 | San Jose EarthquakesvColorado RapidsMLS · United States | 1–0 | MLS · United States |
| 2022-05-08 | PueblavMazatlan FCLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2022-05-08 | VarbergvSiriusAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2022-05-08 | EibarvValladolidLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2022-05-08 | JervvTromsoEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2022-05-08 | Argentinos JrsvUnion de Santa FeCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-05-08 | AZ AlkmaarvAjaxEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2022-05-08 | GianninavPAOKSuper League · Greece | 1–0 | Super League · Greece |
| 2022-05-08 | LeicestervEvertonPremier League · England | 1–2 | Premier League · England |
| 2022-05-08 | SalzburgvWolfsberger ACBundesliga · Austria | 4–0 | Bundesliga · Austria |
| 2022-05-08 | VitessevHeerenveenEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-05-08 | Man CityvNewcastlePremier League · England | 5–0 | Premier League · England |
| 2022-05-08 | New York Red BullsvPortland TimbersMLS · United States | 1–1 | MLS · United States |
| 2022-05-08 | OFI CretevAsteras TripolisSuper League · Greece | 1–0 | Super League · Greece |
| 2022-05-08 | HJKvIlvesVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2022-05-08 | MariehamnvKuPSVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2022-05-08 | ClermontvMontpellierLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-05-08 | Flamengo RJvBotafogo RJSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2022-05-08 | Gil VicentevTondelaPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2022-05-08 | KalmarvHammarbyAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2022-05-08 | Yeni MalatyasporvRizesporSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2022-05-08 | NijmegenvGo Ahead EaglesEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2022-05-08 | BragantinovCorinthiansSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2022-05-08 | Athletico-PRvCearaSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2022-05-08 | FeyenoordvPSV EindhovenEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2022-05-08 | Arsenal TulavKrasnodarPremier League · Russia | 1–1 | Premier League · Russia |
| 2022-05-08 | ReimsvLensLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-05-08 | AEKvPanathinaikosSuper League · Greece | 0–0 | Super League · Greece |
| 2022-05-08 | BrondbyvFC CopenhagenSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2022-05-08 | Ath MadridvReal MadridLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-05-08 | Lokomotiv MoscowvRubin KazanPremier League · Russia | 1–0 | Premier League · Russia |
| 2022-05-08 | Bodo/GlimtvLillestromEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2022-05-08 | Atletico GOvGoiasSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2022-05-08 | RB LeipzigvAugsburgBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2022-05-08 | Piast GliwicevLech PoznanEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2022-05-08 | Defensa y JusticiavPatronatoCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-05-08 | Ham-KamvAalesundEliteserien · Norway | 0–0 | Eliteserien · Norway |
| 2022-05-08 | Gimnasia L.P.vNewells Old BoysCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2022-05-08 | AalborgvMidtjyllandSuperliga · Denmark | 1–2 | Superliga · Denmark |