| 2001-01-21 | IonikosvIraklisSuper League · Greece | 2–2 | Super League · Greece |
| 2001-01-21 | VallecanovLas PalmasLa Liga · Spain | 1–1 | La Liga · Spain |
| 2001-01-21 | CeltavZaragozaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2001-01-21 | BetisvJaenLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2001-01-21 | SampdoriavPescaraSerie B · Italy | 1–1 | Serie B · Italy |
| 2001-01-21 | VicenzavBresciaSerie A · Italy | 1–1 | Serie A · Italy |
| 2001-01-21 | Pacos FerreiravSalgueirosPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2001-01-21 | ChievovSienaSerie B · Italy | 2–1 | Serie B · Italy |
| 2001-01-21 | PistoiesevMonzaSerie B · Italy | 3–1 | Serie B · Italy |
| 2001-01-20 | CardiffvPlymouthLeague Two · England | 4–1 | League Two · England |
| 2001-01-20 | Ath MadridvGetafeLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2001-01-20 | GerminalvLokerenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2001-01-20 | ShrewsburyvCheltenhamLeague Two · England | 1–0 | League Two · England |
| 2001-01-20 | WatfordvFulhamChampionship · England | 1–3 | Championship · England |
| 2001-01-20 | HamiltonvPeterheadLeague Two · Scotland | 3–0 | League Two · Scotland |
| 2001-01-20 | BeverenvAntwerpPro League · Belgium | 2–1 | Pro League · Belgium |
| 2001-01-20 | Leyton OrientvSouthendLeague Two · England | 0–2 | League Two · England |
| 2001-01-20 | ReadingvBristol RvsLeague One · England | 1–0 | League One · England |
| 2001-01-20 | Man UnitedvAston VillaPremier League · England | 2–0 | Premier League · England |
| 2001-01-20 | BurnleyvBarnsleyChampionship · England | 2–1 | Championship · England |
| 2001-01-20 | Queens ParkvArbroathLeague One · Scotland | 1–1 | League One · Scotland |
| 2001-01-20 | TottenhamvSouthamptonPremier League · England | 0–0 | Premier League · England |
| 2001-01-20 | Notts CountyvRotherhamLeague One · England | 4–1 | League One · England |
| 2001-01-20 | LaziovInterSerie A · Italy | 2–0 | Serie A · Italy |
| 2001-01-20 | LeedsvNewcastlePremier League · England | 1–3 | Premier League · England |
| 2001-01-20 | GuimaraesvSp BragaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2001-01-20 |  Ivory Coastv SudanAfrican Cup of Nations qualification | 2–0 | African Cup of Nations qualification |
| 2001-01-20 |  Serbiaplayed as FR Yugoslaviav RomaniaMillennium Cup | 2–0 | Millennium Cup |
| 2001-01-20 | LiersevSt TruidenPro League · Belgium | 2–1 | Pro League · Belgium |
| 2001-01-20 | Bristol CityvNorthamptonLeague One · England | 2–0 | League One · England |
| 2001-01-20 | BolognavVeronaSerie A · Italy | 1–0 | Serie A · Italy |
| 2001-01-20 | PortsmouthvWimbledonChampionship · England | 2–1 | Championship · England |
| 2001-01-20 | Eth AsterasvAthinaikosSuper League · Greece | 2–2 | Super League · Greece |
| 2001-01-20 | DerbyvMan CityPremier League · England | 1–1 | Premier League · England |
| 2001-01-20 | ValenciavBarcelonaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2001-01-20 | WalsallvSwanseaLeague One · England | 5–1 | League One · England |
| 2001-01-20 | CompostelavElcheLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2001-01-20 | LeicestervArsenalPremier League · England | 0–0 | Premier League · England |
| 2001-01-20 | ChelseavIpswichPremier League · England | 4–1 | Premier League · England |
| 2001-01-20 | DarlingtonvChesterfieldLeague Two · England | 0–3 | League Two · England |
| 2001-01-20 | Crystal PalacevGillinghamChampionship · England | 2–2 | Championship · England |
| 2001-01-20 | TorquayvExeterLeague Two · England | 2–1 | League Two · England |
| 2001-01-20 | Sheffield WedsvBoltonChampionship · England | 0–3 | Championship · England |
| 2001-01-20 | CoventryvEvertonPremier League · England | 1–3 | Premier League · England |
| 2001-01-20 | YorkvMacclesfieldLeague Two · England | 1–3 | League Two · England |
| 2001-01-20 |  Chilev IcelandMillennium Cup | 2–0 | Millennium Cup |
| 2001-01-20 | HartlepoolvCarlisleLeague Two · England | 2–2 | League Two · England |
| 2001-01-20 | BoavistavBeira MarPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2001-01-20 | U.Las PalmasvAlbaceteLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2001-01-20 | NorwichvQPRChampionship · England | 1–0 | Championship · England |