| 2016-05-15 | TemperleyvNewells Old BoysLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2016-05-15 | WatfordvSunderlandPremier League · England | 2–2 | Premier League · England |
| 2016-05-15 | InternacionalvChapecoense-SCSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2016-05-15 | Botafogo RJvSao PauloSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2016-05-15 | IndependientevArsenal SarandiLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2016-05-15 | Houston DynamovReal Salt LakeMLS · United States | 1–0 | MLS · United States |
| 2016-05-15 | HeidenheimvBochum2. Bundesliga · Germany | 2–4 | 2. Bundesliga · Germany |
| 2016-05-15 | EspanolvEibarLa Liga · Spain | 4–2 | La Liga · Spain |
| 2016-05-15 | GimnasticvLeganesLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2016-05-15 | New England RevolutionvChicago FireMLS · United States | 2–0 | MLS · United States |
| 2016-05-15 | AldosivivAtl. RafaelaLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2016-05-15 | West BromvLiverpoolPremier League · England | 1–1 | Premier League · England |
| 2016-05-15 | CoritibavCruzeiroSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2016-05-15 | StokevWest HamPremier League · England | 2–1 | Premier League · England |
| 2016-05-15 | EmpolivTorinoSerie A · Italy | 2–1 | Serie A · Italy |
| 2016-05-15 | Piast GliwicevZaglebieEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2016-05-15 | MariehamnvLahtiVeikkausliiga · Finland | 3–0 | Veikkausliiga · Finland |
| 2016-05-15 | PonferradinavLugoLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2016-05-15 | OstersundsvGoteborgAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2016-05-15 | ChelseavLeicesterPremier League · England | 1–1 | Premier League · England |
| 2016-05-15 | AlcorconvAlavesLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2016-05-15 | America MGvFluminenseSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2016-05-15 | FK Anzi MakhackalavM. SaranskPremier League · Russia | 3–0 | Premier League · Russia |
| 2016-05-15 | Greuther FurthvSandhausen2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2016-05-15 | DuisburgvRB Leipzig2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2016-05-15 | Sporting Kansas CityvOrlando CityMLS · United States | 2–1 | MLS · United States |
| 2016-05-15 | AltachvRiedBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2016-05-15 | FenerbahcevGenclerbirligiSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2016-05-15 | FalkenbergsvHackenAllsvenskan · Sweden | 1–4 | Allsvenskan · Sweden |
| 2016-05-15 | PalermovVeronaSerie A · Italy | 3–2 | Serie A · Italy |
| 2016-05-15 | BetisvGetafeLa Liga · Spain | 2–1 | La Liga · Spain |
| 2016-05-15 | LaziovFiorentinaSerie A · Italy | 2–4 | Serie A · Italy |
| 2016-05-15 | ElchevGironaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2016-05-15 | Sp BragavSp LisbonPrimeira Liga · Portugal | 0–4 | Primeira Liga · Portugal |
| 2016-05-15 | Sarmiento JuninvTigreLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2016-05-15 | YanbianvChongqing Liangjiang AthleticSuper League · China | 1–1 | Super League · China |
| 2016-05-15 | Austria ViennavSturm GrazBundesliga · Austria | 3–0 | Bundesliga · Austria |
| 2016-05-15 | CelticvMotherwellPremiership · Scotland | 7–0 | Premiership · Scotland |
| 2016-05-15 | PaderbornvNurnberg2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2016-05-15 | GenoavAtalantaSerie A · Italy | 1–2 | Serie A · Italy |
| 2016-05-15 | Argentinos JrsvLanusLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2016-05-15 | AberdeenvRoss CountyPremiership · Scotland | 0–4 | Premiership · Scotland |
| 2016-05-15 | ArsenalvAston VillaPremier League · England | 4–0 | Premier League · England |
| 2016-05-15 | BenficavNacionalPrimeira Liga · Portugal | 4–1 | Primeira Liga · Portugal |
| 2016-05-15 | Ath Bilbao BvOsasunaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2016-05-15 | NorrkopingvSundsvallAllsvenskan · Sweden | 3–1 | Allsvenskan · Sweden |
| 2016-05-15 | Frankfurt FSVvMunich 18602. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2016-05-15 | Columbus CrewvColorado RapidsMLS · United States | 1–1 | MLS · United States |
| 2016-05-15 | LlagosteravCordobaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2016-05-15 | KarlsruhevBielefeld2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |