| 2010-02-06 | Sp LisbonvAcademicaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2010-02-06 | LokerenvMechelenPro League · Belgium | 2–1 | Pro League · Belgium |
| 2010-02-06 | GrimsbyvNotts CountyLeague Two · England | 0–1 | League Two · England |
| 2010-02-06 | BurtonvPort ValeLeague Two · England | 1–0 | League Two · England |
| 2010-02-06 | NicevLilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-02-06 | MacclesfieldvShrewsburyLeague Two · England | 0–1 | League Two · England |
| 2010-02-06 | ValenciavValladolidLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-02-06 | TottenhamvAston VillaPremier League · England | 0–0 | Premier League · England |
| 2010-02-06 | BurnleyvWest HamPremier League · England | 2–1 | Premier League · England |
| 2010-02-06 | Queens ParkvStranraerLeague Two · Scotland | 2–5 | League Two · Scotland |
| 2010-02-06 | AnderlechtvSt TruidenPro League · Belgium | 1–2 | Pro League · Belgium |
| 2010-02-06 | WolfsburgvBayern MunichBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2010-02-06 | Man UnitedvPortsmouthPremier League · England | 5–0 | Premier League · England |
| 2010-02-06 | GraysvRushden & DNational League · England | 0–3 | National League · England |
| 2010-02-06 | PeterborovQPRChampionship · England | 1–0 | Championship · England |
| 2010-02-06 | SwanseavPrestonChampionship · England | 2–0 | Championship · England |
| 2010-02-06 | BrechinvAlloaLeague One · Scotland | 1–1 | League One · Scotland |
| 2010-02-06 | PSV EindhovenvDen HaagEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-02-06 | EskisehirsporvBuyuksehyrSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2010-02-06 | MantovavAscoliSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-02-06 | BochumvLeverkusenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2010-02-06 | TranmerevOldhamLeague One · England | 0–1 | League One · England |
| 2010-02-06 | ExetervSouthamptonLeague One · England | 1–1 | League One · England |
| 2010-02-06 | HeerenveenvUtrechtEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-02-06 | Roda JCvSpartaEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2010-02-06 | MurciavSociedadLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-02-06 | Crawley TownvCambridgeNational League · England | 1–0 | National League · England |
| 2010-02-06 | SochauxvNancyLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-02-06 | GrenoblevAuxerreLigue 1 · France | 5–0 | Ligue 1 · France |
| 2010-02-06 | ArisvPanthrakikosSuper League · Greece | 0–2 | Super League · Greece |
| 2010-02-06 | FreiburgvSchalke 04Bundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2010-02-06 | GironavGimnasticLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2010-02-06 | SwindonvCharltonLeague One · England | 1–1 | League One · England |
| 2010-02-06 | HerefordvTorquayLeague Two · England | 1–0 | League Two · England |
| 2010-02-06 | HartlepoolvLeedsLeague One · England | 2–2 | League One · England |
| 2010-02-06 | HuddersfieldvCarlisleLeague One · England | 1–1 | League One · England |
| 2010-02-06 | BradfordvBuryLeague Two · England | 0–1 | League Two · England |
| 2010-02-06 | FC KolnvHamburgBundesliga · Germany | 3–3 | Bundesliga · Germany |
| 2010-02-06 | SetubalvBenficaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-02-06 | BarcelonavGetafeLa Liga · Spain | 2–1 | La Liga · Spain |
| 2010-02-06 | TriestinavSassuoloSerie B · Italy | 0–1 | Serie B · Italy |
| 2010-02-06 | BarnsleyvWatfordChampionship · England | 1–0 | Championship · England |
| 2010-02-06 | AnconavAlbinoleffeSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-02-06 | KayserisporvGalatasaraySüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2010-02-06 | LensvLe MansLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-02-06 | LivornovJuventusSerie A · Italy | 1–1 | Serie A · Italy |
| 2010-02-06 | WalsallvBristol RvsLeague One · England | 0–0 | League One · England |
| 2010-02-06 | Bristol CityvCoventryChampionship · England | 1–1 | Championship · England |
| 2010-02-06 | DoncastervReadingChampionship · England | 1–2 | Championship · England |
| 2010-02-06 | HistonvHayes & YeadingNational League · England | 3–3 | National League · England |