| 2009-02-22 | FiorentinavChievoSerie A · Italy | 2–1 | Serie A · Italy |
| 2009-02-22 | LiverpoolvMan CityPremier League · England | 1–1 | Premier League · England |
| 2009-02-22 | St EtiennevBordeauxLigue 1 · France | 1–1 | Ligue 1 · France |
| 2009-02-22 | LeccevLazioSerie A · Italy | 0–2 | Serie A · Italy |
| 2009-02-22 | La CorunavValenciaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2009-02-22 | AnderlechtvStandardPro League · Belgium | 4–2 | Pro League · Belgium |
| 2009-02-22 | GetafevAth BilbaoLa Liga · Spain | 1–1 | La Liga · Spain |
| 2009-02-22 | ParmavBresciaSerie B · Italy | 1–0 | Serie B · Italy |
| 2009-02-22 | CordobavXerezLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2009-02-22 | AlicantevGimnasticLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2009-02-22 | AhlenvOberhausen2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2009-02-22 | Lillev MonacoLigue 1 · France | 2–1 | Ligue 1 · France |
| 2009-02-22 | KoblenzvGreuther Furth2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2009-02-22 | NavalvSp BragaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2009-02-22 | GalatasarayvKocaelisporSüper Lig · Turkey | 2–5 | Süper Lig · Turkey |
| 2009-02-22 | PanserraikosvLevadeiakosSuper League · Greece | 1–0 | Super League · Greece |
| 2009-02-22 | UtrechtvNijmegenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2009-02-22 | MallorcavSantanderLa Liga · Spain | 1–0 | La Liga · Spain |
| 2009-02-21 | ArbroathvQueens ParkLeague One · Scotland | 3–0 | League One · Scotland |
| 2009-02-21 | SassuolovRiminiSerie B · Italy | 1–0 | Serie B · Italy |
| 2009-02-21 | PartickvMortonChampionship · Scotland | 1–0 | Championship · Scotland |
| 2009-02-21 | PiacenzavAlbinoleffeSerie B · Italy | 1–2 | Serie B · Italy |
| 2009-02-21 | AberdeenvDundee UnitedPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2009-02-21 | StokevPortsmouthPremier League · England | 2–2 | Premier League · England |
| 2009-02-21 | HuescavTenerifeLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2009-02-21 | Queen of SthvSt JohnstoneChampionship · Scotland | 3–3 | Championship · Scotland |
| 2009-02-21 | Inverness CvHibernianPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2009-02-21 | RochdalevBrentfordLeague Two · England | 1–2 | League Two · England |
| 2009-02-21 | SevillavAth MadridLa Liga · Spain | 1–0 | La Liga · Spain |
| 2009-02-21 | Man UnitedvBlackburnPremier League · England | 2–1 | Premier League · England |
| 2009-02-21 | BarnetvBradfordLeague Two · England | 4–1 | League Two · England |
| 2009-02-21 | PeterheadvStranraerLeague One · Scotland | 1–0 | League One · Scotland |
| 2009-02-21 | TubizevWaregemPro League · Belgium | 0–6 | Pro League · Belgium |
| 2009-02-21 | CoventryvBirminghamChampionship · England | 1–0 | Championship · England |
| 2009-02-21 | AvellinovVicenzaSerie B · Italy | 1–0 | Serie B · Italy |
| 2009-02-21 | ArsenalvSunderlandPremier League · England | 0–0 | Premier League · England |
| 2009-02-21 | ElginvAlbion RvsLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2009-02-21 | PanathinaikosvPanioniosSuper League · Greece | 2–1 | Super League · Greece |
| 2009-02-21 | BielefeldvBochumBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2009-02-21 | HeraclesvAZ AlkmaarEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2009-02-21 | StenhousemuirvBerwickLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2009-02-21 | LeedsvCheltenhamLeague One · England | 2–0 | League One · England |
| 2009-02-21 | BarnsleyvCharltonChampionship · England | 0–0 | Championship · England |
| 2009-02-21 | Kettering TownvTorquayNational League · England | 2–1 | National League · England |
| 2009-02-21 | EmpolivCittadellaSerie B · Italy | 0–1 | Serie B · Italy |
| 2009-02-21 | Annan AthleticvForfarLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2009-02-21 | M'gladbachvHannoverBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2009-02-21 | MantovavTriestinaSerie B · Italy | 0–1 | Serie B · Italy |
| 2009-02-21 | NorthamptonvWalsallLeague One · England | 0–2 | League One · England |
| 2009-02-21 | Le HavrevAuxerreLigue 1 · France | 1–2 | Ligue 1 · France |