| 2010-02-20 | MontrosevElginLeague Two · Scotland | 0–4 | League Two · Scotland |
| 2010-02-20 | NicevLorientLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-02-20 | OlhanensevSp LisbonPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2010-02-20 | HerefordvBurtonLeague Two · England | 3–4 | League Two · England |
| 2010-02-20 | CastellonvCartagenaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2010-02-20 | Forest GreenvCambridgeNational League · England | 1–1 | National League · England |
| 2010-02-20 | BetisvAlbaceteLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2010-02-20 | ScunthorpevWatfordChampionship · England | 2–2 | Championship · England |
| 2010-02-20 | St EtiennevMontpellierLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-02-20 | Hansa RostockvAugsburg2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2010-02-20 | Paris SGvToulouseLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-02-20 | LutonvAFC WimbledonNational League · England | 1–2 | National League · England |
| 2010-02-20 | PiacenzavAlbinoleffeSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-02-20 | NorwichvSouthamptonLeague One · England | 0–2 | League One · England |
| 2010-02-20 | NewcastlevPrestonChampionship · England | 3–0 | Championship · England |
| 2010-02-20 | PortsmouthvStokePremier League · England | 1–2 | Premier League · England |
| 2010-02-20 | GenoavUdineseSerie A · Italy | 3–0 | Serie A · Italy |
| 2010-02-20 | WrexhamvCrawley TownNational League · England | 2–0 | National League · England |
| 2010-02-20 | IraklisvLevadeiakosSuper League · Greece | 1–1 | Super League · Greece |
| 2010-02-20 | CardiffvBarnsleyChampionship · England | 0–2 | Championship · England |
| 2010-02-20 | Milton Keynes DonsvSouthendLeague One · England | 3–1 | League One · England |
| 2010-02-20 | GentvSt TruidenPro League · Belgium | 0–1 | Pro League · Belgium |
| 2010-02-20 | AnconavPadovaSerie B · Italy | 2–2 | Serie B · Italy |
| 2010-02-20 |  Sri Lankav BangladeshAFC Challenge Cup | 3–0 | AFC Challenge Cup |
| 2010-02-20 | DundeevPartickChampionship · Scotland | 1–0 | Championship · Scotland |
| 2010-02-20 | BerwickvAnnan AthleticLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2010-02-20 | West HamvHullPremier League · England | 3–0 | Premier League · England |
| 2010-02-20 | BournemouthvMacclesfieldLeague Two · England | 1–1 | League Two · England |
| 2010-02-20 | ExetervStockportLeague One · England | 0–1 | League One · England |
| 2010-02-20 | La CorunavXerezLa Liga · Spain | 2–1 | La Liga · Spain |
| 2010-02-20 | DunfermlinevAyrChampionship · Scotland | 0–1 | Championship · Scotland |
| 2010-02-20 | GillinghamvBristol RvsLeague One · England | 1–0 | League One · England |
| 2010-02-20 | GallipolivVicenzaSerie B · Italy | 0–5 | Serie B · Italy |
| 2010-02-20 | BlackpoolvReadingChampionship · England | 2–0 | Championship · England |
| 2010-02-20 | GuimaraesvLeixoesPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2010-02-20 | KilmarnockvSt MirrenPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2010-02-20 | Eastbourne BoroughvAltrinchamNational League · England | 2–2 | National League · England |
| 2010-02-20 | DortmundvHannoverBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2010-02-20 | NAC BredavUtrechtEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2010-02-20 | WycombevMillwallLeague One · England | 1–0 | League One · England |
| 2010-02-20 | HartlepoolvHuddersfieldLeague One · England | 0–2 | League One · England |
| 2010-02-20 | WesterlovCharleroiPro League · Belgium | 4–0 | Pro League · Belgium |
| 2010-02-20 | TranmerevLeyton OrientLeague One · England | 2–1 | League One · England |
| 2010-02-20 | WolvesvChelseaPremier League · England | 0–2 | Premier League · England |
| 2010-02-20 | Nott'm ForestvMiddlesbroughChampionship · England | 1–0 | Championship · England |
| 2010-02-20 | FrosinonevEmpoliSerie B · Italy | 3–1 | Serie B · Italy |
| 2010-02-20 | AccringtonvBradfordLeague Two · England | 2–0 | League Two · England |
| 2010-02-20 | QPRvDoncasterChampionship · England | 2–1 | Championship · England |
| 2010-02-20 | Villarreal BvRecreativoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-02-20 | EskisehirsporvGenclerbirligiSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |