| 2010-02-21 |  Turkmenistanv KyrgyzstanAFC Challenge Cup | 1–0 | AFC Challenge Cup |
| 2010-02-21 | FreiburgvHerthaBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2010-02-21 | AlmeriavAth MadridLa Liga · Spain | 1–0 | La Liga · Spain |
| 2010-02-21 | PortovSp BragaPrimeira Liga · Portugal | 5–1 | Primeira Liga · Portugal |
| 2010-02-21 | WiganvTottenhamPremier League · England | 0–3 | Premier League · England |
| 2010-02-21 | KasimpasavGaziantepsporSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2010-02-21 | PAOKvPanathinaikosSuper League · Greece | 2–1 | Super League · Greece |
| 2010-02-21 | FeyenoordvDen HaagEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2010-02-21 | Man CityvLiverpoolPremier League · England | 0–0 | Premier League · England |
| 2010-02-21 | GuingampvBrestLigue 2 · France | 0–0 | Ligue 2 · France |
| 2010-02-21 | AtromitosvAsteras TripolisSuper League · Greece | 0–0 | Super League · Greece |
| 2010-02-21 | SetubalvNavalPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2010-02-21 | Bristol CityvWest BromChampionship · England | 2–1 | Championship · England |
| 2010-02-21 | LarisavPanthrakikosSuper League · Greece | 0–2 | Super League · Greece |
| 2010-02-21 | AnkaragucuvAntalyasporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2010-02-21 | Frankfurt FSVvKarlsruhe2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2010-02-21 | Real MadridvVillarrealLa Liga · Spain | 6–2 | La Liga · Spain |
| 2010-02-21 | BolognavJuventusSerie A · Italy | 1–2 | Serie A · Italy |
| 2010-02-21 | MarseillevNancyLigue 1 · France | 3–1 | Ligue 1 · France |
| 2010-02-21 | WolfsburgvSchalke 04Bundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-02-21 | RomavCataniaSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-02-21 | BlackburnvBoltonPremier League · England | 3–0 | Premier League · England |
| 2010-02-21 | BesiktasvGalatasaraySüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2010-02-21 | AEKvArisSuper League · Greece | 1–0 | Super League · Greece |
| 2010-02-21 | BarivMilanSerie A · Italy | 0–2 | Serie A · Italy |
| 2010-02-21 | HeartsvHamiltonPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2010-02-21 | GimnasticvHuescaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2010-02-21 | AjaxvVitesseEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2010-02-21 | Ath BilbaovTenerifeLa Liga · Spain | 4–1 | La Liga · Spain |
| 2010-02-21 | GianninavPanioniosSuper League · Greece | 2–3 | Super League · Greece |
| 2010-02-21 | RennesvLilleLigue 1 · France | 1–2 | Ligue 1 · France |
| 2010-02-21 | OsasunavValladolidLa Liga · Spain | 1–1 | La Liga · Spain |
| 2010-02-21 | SochauxvLyonLigue 1 · France | 0–4 | Ligue 1 · France |
| 2010-02-21 | PalermovLazioSerie A · Italy | 3–1 | Serie A · Italy |
| 2010-02-21 | FulhamvBirminghamPremier League · England | 2–1 | Premier League · England |
| 2010-02-21 | PSV EindhovenvSpartaEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2010-02-21 | CeltavCordobaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2010-02-21 | CadizvHerculesLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2010-02-20 | NijmegenvGroningenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2010-02-20 | BoulognevLe MansLigue 1 · France | 1–3 | Ligue 1 · France |
| 2010-02-20 | GrimsbyvLincolnLeague Two · England | 2–2 | League Two · England |
| 2010-02-20 | IntervSampdoriaSerie A · Italy | 0–0 | Serie A · Italy |
| 2010-02-20 | WalsallvBrentfordLeague One · England | 2–1 | League One · England |
| 2010-02-20 | MotherwellvHibernianPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2010-02-20 | FC KolnvStuttgartBundesliga · Germany | 1–5 | Bundesliga · Germany |
| 2010-02-20 | MainzvBochumBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2010-02-20 | RochdalevDag and RedLeague Two · England | 3–1 | League Two · England |
| 2010-02-20 | CelticvDundee UnitedPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2010-02-20 | DerbyvSwanseaChampionship · England | 0–1 | Championship · England |
| 2010-02-20 | Lensv MonacoLigue 1 · France | 3–0 | Ligue 1 · France |