| 2008-12-06 | M'gladbachvLeverkusenBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2008-12-06 | Eastbourne BoroughvNorthwichNational League · England | 4–1 | National League · England |
| 2008-12-06 | FulhamvMan CityPremier League · England | 1–1 | Premier League · England |
| 2008-12-06 | OFIvArisSuper League · Greece | 0–1 | Super League · Greece |
| 2008-12-06 | AnderlechtvTubizePro League · Belgium | 5–1 | Pro League · Belgium |
| 2008-12-06 | BlackpoolvCharltonChampionship · England | 2–0 | Championship · England |
| 2008-12-06 | Sp GijonvAth MadridLa Liga · Spain | 2–5 | La Liga · Spain |
| 2008-12-06 | GaziantepsporvKayserisporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2008-12-06 | PiacenzavTriestinaSerie B · Italy | 0–2 | Serie B · Italy |
| 2008-12-06 | Man UnitedvSunderlandPremier League · England | 1–0 | Premier League · England |
| 2008-12-06 | BirminghamvWatfordChampionship · England | 3–2 | Championship · England |
| 2008-12-06 | Sheffield UnitedvBurnleyChampionship · England | 2–3 | Championship · England |
| 2008-12-06 | BoltonvChelseaPremier League · England | 0–2 | Premier League · England |
| 2008-12-06 | Las PalmasvCeltaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2008-12-06 | East FifevAlloaLeague One · Scotland | 1–0 | League One · Scotland |
| 2008-12-06 | St EtiennevLe HavreLigue 1 · France | 2–0 | Ligue 1 · France |
| 2008-12-06 | VallecanovSalamancaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2008-12-06 | AldershotvWycombeLeague Two · England | 3–2 | League Two · England |
| 2008-12-06 | AlavesvGimnasticLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2008-12-06 | Roda JCvVitesseEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2008-12-06 | QPRvWolvesChampionship · England | 1–0 | Championship · England |
| 2008-12-06 | Inverness CvDundee UnitedPremiership · Scotland | 1–3 | Premiership · Scotland |
| 2008-12-06 | Queens ParkvArbroathLeague One · Scotland | 1–2 | League One · Scotland |
| 2008-12-06 | Crawley TownvAltrinchamNational League · England | 4–0 | National League · England |
| 2008-12-06 | StockportvPeterboroLeague One · England | 1–3 | League One · England |
| 2008-12-06 | NacionalvBelenensesPrimeira Liga · Portugal | 4–2 | Primeira Liga · Portugal |
| 2008-12-06 | OldhamvBrightonLeague One · England | 1–1 | League One · England |
| 2008-12-06 | TorquayvCambridgeNational League · England | 0–0 | National League · England |
| 2008-12-06 | BarcelonavValenciaLa Liga · Spain | 4–0 | La Liga · Spain |
| 2008-12-06 | PSV EindhovenvGroningenEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2008-12-06 | AZ AlkmaarvHeraclesEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2008-12-06 | SouthamptonvSheffield WedsChampionship · England | 1–1 | Championship · England |
| 2008-12-06 | StandardvWaregemPro League · Belgium | 1–2 | Pro League · Belgium |
| 2008-12-06 | WrexhamvKettering TownNational League · England | 2–1 | National League · England |
| 2008-12-06 | KidderminstervSalisburyNational League · England | 3–2 | National League · England |
| 2008-12-06 | PanserraikosvErgotelisSuper League · Greece | 0–2 | Super League · Greece |
| 2008-12-06 | MarseillevNiceLigue 1 · France | 2–1 | Ligue 1 · France |
| 2008-12-06 | ZaragozavHuescaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2008-12-06 | Rushden & DvBarrowNational League · England | 1–1 | National League · England |
| 2008-12-06 | ArsenalvWiganPremier League · England | 1–0 | Premier League · England |
| 2008-12-06 | XanthivPanathinaikosSuper League · Greece | 1–2 | Super League · Greece |
| 2008-12-06 | Notts CountyvMorecambeLeague Two · England | 1–0 | League Two · England |
| 2008-12-06 | ShrewsburyvRotherhamLeague Two · England | 1–0 | League Two · England |
| 2008-12-06 | FrosinonevSassuoloSerie B · Italy | 2–2 | Serie B · Italy |
| 2008-12-06 | CardiffvPrestonChampionship · England | 2–0 | Championship · England |
| 2008-12-06 | CaenvRennesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2008-12-06 | ExetervLincolnLeague Two · England | 2–1 | League Two · England |
| 2008-12-06 | BresciavAlbinoleffeSerie B · Italy | 1–0 | Serie B · Italy |
| 2008-12-06 | BerwickvStenhousemuirLeague Two · Scotland | 3–2 | League Two · Scotland |
| 2008-12-06 | NewcastlevStokePremier League · England | 2–2 | Premier League · England |