| 2021-08-02 | Din. BucurestivAcademica ClinceniSuperliga · Romania | 3–1 | Superliga · Romania |
| 2021-08-02 | Akhmat GroznyvSochiPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-08-02 | Toronto FCvNashville SCMLS · United States | 1–1 | MLS · United States |
| 2021-08-02 | Santos LagunavCruz AzulLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-02 | Estudiantes L.P.vArsenal SarandiLiga Profesional · Argentina | 4–0 | Liga Profesional · Argentina |
| 2021-08-02 | Lechia GdanskvWisla PlockEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-08-02 | Henan Songshan LongmenvChongqing Liangjiang AthleticSuper League · China | 1–0 | Super League · China |
| 2021-08-02 | Inter TurkuvHonkaVeikkausliiga · Finland | 2–2 | Veikkausliiga · Finland |
| 2021-08-02 | SonderjyskevNordsjaellandSuperliga · Denmark | 0–2 | Superliga · Denmark |
| 2021-08-02 | Sepsi Sf. GheorghevMioveniSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-08-02 | PatronatovNewells Old BoysLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-08-02 | Argentinos JrsvCentral CordobaLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-02 | San LorenzovBanfieldLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-02 | Rosario CentralvAldosiviLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-08-02 | ShenzhenvGuangzhou CitySuper League · China | 0–1 | Super League · China |
| 2021-08-02 | AuxerrevGrenobleLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-08-02 | Atletico GOvAmerica MGSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-08-02 | SiriusvOrebroAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-08-02 | Guangzhou FCvCangzhouSuper League · China | 5–2 | Super League · China |
| 2021-08-02 | CearavFortalezaSerie A · Brazil | 3–1 | Serie A · Brazil |
| 2021-08-02 | KilmarnockvAyrChampionship · Scotland | 2–0 | Championship · Scotland |
| 2021-08-01 | FK RostovvZenitPremier League · Russia | 2–4 | Premier League · Russia |
| 2021-08-01 | Philadelphia UnionvChicago FireMLS · United States | 1–1 | MLS · United States |
| 2021-08-01 | St. GilloisevClub BruggePro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-08-01 | ServettevLuganoSuper League · Switzerland | 0–2 | Super League · Switzerland |
| 2021-08-01 | PlatensevIndependienteLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-01 | InternacionalvCuiabaSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-08-01 | AtlasvJuarezLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-08-01 | Houston DynamovReal Salt LakeMLS · United States | 0–0 | MLS · United States |
| 2021-08-01 | River PlatevHuracanLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-01 | CorinthiansvFlamengo RJSerie A · Brazil | 1–3 | Serie A · Brazil |
| 2021-08-01 | AntwerpvKortrijkPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-08-01 | AarhusvRanders FCSuperliga · Denmark | 1–2 | Superliga · Denmark |
| 2021-08-01 | Defensa y JusticiavGimnasia L.P.Liga Profesional · Argentina | 3–2 | Liga Profesional · Argentina |
| 2021-08-01 | DjurgardenvHackenAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2021-08-01 | Atletico-MGvAthletico-PRSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-08-01 | UTA AradvFCSBSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-08-01 | Austin FCvColorado RapidsMLS · United States | 0–1 | MLS · United States |
| 2021-08-01 | KalmarvMjallbyAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-08-01 | Holstein KielvSchalke 042. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2021-08-01 | Chapecoense-SCvSantosSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-08-01 | CracoviavSlask WroclawEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-08-01 | GentvBeerschot VAPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-08-01 | FC CincinnativDC UnitedMLS · United States | 0–0 | MLS · United States |
| 2021-08-01 | Erzgebirge AuevSt Pauli2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-08-01 | TolucavTigres UANLLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-08-01 | Univ. CraiovavFC BotosaniSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-08-01 | AberdeenvDundee UnitedPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-08-01 | St. GallenvLuzernSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2021-08-01 | BaselvSionSuper League · Switzerland | 6–1 | Super League · Switzerland |