| 2021-08-07 | Albion RvsvStenhousemuirLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2021-08-07 | RiedvAdmiraBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-08-07 | Beerschot VAvSt. GilloisePro League · Belgium | 0–3 | Pro League · Belgium |
| 2021-08-07 | NorthamptonvPort ValeLeague Two · England | 1–0 | League Two · England |
| 2021-08-07 | Queens ParkvCove RangersLeague One · Scotland | 2–0 | League One · Scotland |
| 2021-08-07 | IpswichvMorecambeLeague One · England | 2–2 | League One · England |
| 2021-08-07 | DoncastervAFC WimbledonLeague One · England | 1–2 | League One · England |
| 2021-08-07 | CaenvSochauxLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-08-07 | CardiffvBarnsleyChampionship · England | 1–1 | Championship · England |
| 2021-08-07 | A. KlagenfurtvHartbergBundesliga · Austria | 4–3 | Bundesliga · Austria |
| 2021-08-07 | LyonvBrestLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-08-07 | HamiltonvMortonChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-08-07 | BoltonvMilton Keynes DonsLeague One · England | 3–3 | League One · England |
| 2021-08-07 | Academica ClincenivU Craiova 1948Superliga · Romania | 1–2 | Superliga · Romania |
| 2021-08-07 | KortrijkvGenkPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-08-07 | Spartak MoscowvPari NNPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-08-07 | HarrogatevRochdaleLeague Two · England | 3–2 | League Two · England |
| 2021-08-07 | AuxerrevAjaccioLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-08-07 | TroyesvParis SGLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-08-07 | StokevReadingChampionship · England | 3–2 | Championship · England |
| 2021-08-07 | Mazatlan FCvMonterreyLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-07 | Club TijuanavTolucaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-08-07 | DerbyvHuddersfieldChampionship · England | 1–1 | Championship · England |
| 2021-08-07 | DijonvRodezLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-08-07 | CrewevCheltenhamLeague One · England | 1–1 | League One · England |
| 2021-08-07 | Pau FCvToulouseLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-08-07 | ZenitvKrasnodarPremier League · Russia | 3–2 | Premier League · Russia |
| 2021-08-07 | PrestonvHullChampionship · England | 1–4 | Championship · England |
| 2021-08-07 | FC ArgesvFC Rapid BucurestiSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-08-07 | OldhamvNewport CountyLeague Two · England | 0–1 | League Two · England |
| 2021-08-07 | StevenagevBarrowLeague Two · England | 1–0 | League Two · England |
| 2021-08-07 | Athletico-PRvSao PauloSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-08-07 | ScunthorpevSwindonLeague Two · England | 1–3 | League Two · England |
| 2021-08-07 | HalmstadvMalmo FFAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-08-07 | SionvYoung BoysSuper League · Switzerland | 1–0 | Super League · Switzerland |
| 2021-08-07 | AroucavEstorilPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-08-07 | StranraervAnnan AthleticLeague Two · Scotland | 0–3 | League Two · Scotland |
| 2021-08-07 | Dundee UnitedvRangersPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-08-07 | ExetervBradfordLeague Two · England | 0–0 | League Two · England |
| 2021-08-07 | Inverness CvRaith RvsChampionship · Scotland | 1–0 | Championship · Scotland |
| 2021-08-07 | MoreirensevBenficaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-08-07 | AyrvArbroathChampionship · Scotland | 2–2 | Championship · Scotland |
| 2021-08-07 | DunkerquevNiortLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-08-07 | MontrosevClydeLeague One · Scotland | 2–2 | League One · Scotland |
| 2021-08-07 | St TruidenvWaregemPro League · Belgium | 1–3 | Pro League · Belgium |
| 2021-08-07 | Newells Old BoysvPlatenseLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-08-07 | ShrewsburyvBurtonLeague One · England | 0–1 | League One · England |
| 2021-08-07 | AmiensvQuevilly RouenLigue 2 · France | 1–3 | Ligue 2 · France |
| 2021-08-07 | GrasshoppersvLausanneSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2021-08-07 | AC OuluvMariehamnVeikkausliiga · Finland | 1–0 | Veikkausliiga · Finland |