| 2021-08-08 | PalmeirasvFortalezaSerie A · Brazil | 2–3 | Serie A · Brazil |
| 2021-08-08 | KhimkivFK RostovPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-08-08 | LivingstonvAberdeenPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-08-08 | BordeauxvClermontLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-08-08 | Chicago FirevNew York Red BullsMLS · United States | 2–1 | MLS · United States |
| 2021-08-08 | Inter MiamivNashville SCMLS · United States | 2–1 | MLS · United States |
| 2021-08-08 | PortovBelenensesPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-08-08 | GoteborgvHammarbyAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-08-08 | MontpelliervMarseilleLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-08-07 | QPRvMillwallChampionship · England | 1–1 | Championship · England |
| 2021-08-07 | FalkirkvPeterheadLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-08-07 | HartlepoolvCrawley TownLeague Two · England | 1–0 | League Two · England |
| 2021-08-07 | Union de Santa FevSan LorenzoLiga Profesional · Argentina | 4–0 | Liga Profesional · Argentina |
| 2021-08-07 | Sligo RoversvFinn HarpsPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-08-07 | NecaxavCruz AzulLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-08-07 | JagielloniavTermalica B-B.Ekstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-08-07 | Queen of SthvKilmarnockChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-08-07 | WaterfordvBohemiansPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2021-08-07 | WycombevAccringtonLeague One · England | 2–1 | League One · England |
| 2021-08-07 | Le HavrevParis FCLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-08-07 | RotherhamvPlymouthLeague One · England | 2–0 | League One · England |
| 2021-08-07 | BlackburnvSwanseaChampionship · England | 2–1 | Championship · England |
| 2021-08-07 | ForfarvEdinburgh CityLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2021-08-07 | StirlingvKelty HeartsLeague Two · Scotland | 1–3 | League Two · Scotland |
| 2021-08-07 | Guadalajara ChivasvJuarezLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2021-08-07 | CarlislevColchesterLeague Two · England | 0–0 | League Two · England |
| 2021-08-07 | SalfordvLeyton OrientLeague Two · England | 1–1 | League Two · England |
| 2021-08-07 | DumbartonvAirdrie UtdLeague One · Scotland | 2–2 | League One · Scotland |
| 2021-08-07 | Forest GreenvSuttonLeague Two · England | 2–1 | League Two · England |
| 2021-08-07 | ValenciennesvNimesLigue 2 · France | 0–3 | Ligue 2 · France |
| 2021-08-07 | HuracanvLanusLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-08-07 | OrebrovMjallbyAllsvenskan · Sweden | 2–2 | Allsvenskan · Sweden |
| 2021-08-07 | CharltonvSheffield WedsLeague One · England | 0–0 | League One · England |
| 2021-08-07 | Fleetwood TownvPortsmouthLeague One · England | 0–1 | League One · England |
| 2021-08-07 | LutonvPeterboroChampionship · England | 3–0 | Championship · England |
| 2021-08-07 | TranmerevWalsallLeague Two · England | 1–0 | League Two · England |
| 2021-08-07 | GillinghamvLincolnLeague One · England | 1–1 | League One · England |
| 2021-08-07 | MaritimovSp BragaPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-08-07 | Arsenal TulavKrylya SovetovPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-08-07 | MechelenvEupenPro League · Belgium | 1–3 | Pro League · Belgium |
| 2021-08-07 | SunderlandvWiganLeague One · England | 2–1 | League One · England |
| 2021-08-07 | BanfieldvTalleres CordobaLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-08-07 | Sheffield UnitedvBirminghamChampionship · England | 0–1 | Championship · England |
| 2021-08-07 | Bristol CityvBlackpoolChampionship · England | 1–1 | Championship · England |
| 2021-08-07 | CambridgevOxfordLeague One · England | 1–1 | League One · England |
| 2021-08-07 | GrenoblevGuingampLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-08-07 | MansfieldvBristol RvsLeague Two · England | 2–1 | League Two · England |
| 2021-08-07 | Gornik Z.vStal MielecEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-08-07 | DunfermlinevPartickChampionship · Scotland | 0–3 | Championship · Scotland |
| 2021-08-07 | CowdenbeathvElginLeague Two · Scotland | 3–1 | League Two · Scotland |