| 2021-08-08 | CoventryvNott'm ForestChampionship · England | 2–1 | Championship · England |
| 2021-08-08 | MetzvLilleLigue 1 · France | 3–3 | Ligue 1 · France |
| 2021-08-08 | BaselvServetteSuper League · Switzerland | 5–1 | Super League · Switzerland |
| 2021-08-08 | Guangzhou CityvShandong TaishanSuper League · China | 1–3 | Super League · China |
| 2021-08-08 | Colorado RapidsvSporting Kansas CityMLS · United States | 0–0 | MLS · United States |
| 2021-08-08 | Rubin KazanvAkhmat GroznyPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-08-08 | Portland TimbersvReal Salt LakeMLS · United States | 3–2 | MLS · United States |
| 2021-08-08 | Pacos FerreiravFamalicaoPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-08-08 | Tigres UANLvSantos LagunaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-08 | Boca JuniorsvArgentinos JrsLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-08 | Flamengo RJvInternacionalSerie A · Brazil | 0–4 | Serie A · Brazil |
| 2021-08-08 | DjurgardenvAIKAllsvenskan · Sweden | 1–4 | Allsvenskan · Sweden |
| 2021-08-08 | WislavRakowEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-08-08 | HibernianvRoss CountyPremiership · Scotland | 3–0 | Premiership · Scotland |
| 2021-08-08 | HackenvOstersundsAllsvenskan · Sweden | 5–0 | Allsvenskan · Sweden |
| 2021-08-08 | TirolvLASKBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-08-08 | AnderlechtvSeraingPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-08-08 | New England RevolutionvPhiladelphia UnionMLS · United States | 2–1 | MLS · United States |
| 2021-08-08 | StabaekvSarpsborg 08Eliteserien · Norway | 3–1 | Eliteserien · Norway |
| 2021-08-08 | KuPSvLahtiVeikkausliiga · Finland | 2–2 | Veikkausliiga · Finland |
| 2021-08-08 | Velez SarsfieldvColon Santa FELiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-08-08 | FC CopenhagenvBrondbySuperliga · Denmark | 4–2 | Superliga · Denmark |
| 2021-08-08 | Dynamo MoscowvCSKA MoscowPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-08-08 | TondelavSanta ClaraPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2021-08-08 | UNAM PumasvAtl. San LuisLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2021-08-08 | CelticvDundeePremiership · Scotland | 6–0 | Premiership · Scotland |
| 2021-08-08 | SantosvCorinthiansSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-08-08 | LuganovSt. GallenSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2021-08-08 | Chindia TargovistevDin. BucurestiSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-08-08 | VikingvKristiansundEliteserien · Norway | 3–2 | Eliteserien · Norway |
| 2021-08-08 | HakavInter TurkuVeikkausliiga · Finland | 1–0 | Veikkausliiga · Finland |
| 2021-08-08 | OostendevGentPro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-08-08 | CuiabavBahiaSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-08-08 | Pogon SzczecinvPiast GliwiceEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-08-08 | SalzburgvAustria ViennaBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2021-08-08 | Chongqing Liangjiang AthleticvGuangzhou FCSuper League · China | 1–5 | Super League · China |
| 2021-08-08 | Club AmericavPueblaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-08-08 | St EtiennevLorientLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-08-08 | JuventudevAtletico-MGSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-08-08 | Qingdao FCvHenan Songshan LongmenSuper League · China | 0–1 | Super League · China |
| 2021-08-08 | FulhamvMiddlesbroughChampionship · England | 1–1 | Championship · England |
| 2021-08-08 | Minnesota UnitedvHouston DynamoMLS · United States | 2–0 | MLS · United States |
| 2021-08-08 | LuzernvZurichSuper League · Switzerland | 1–3 | Super League · Switzerland |
| 2021-08-08 | GuimaraesvPortimonensePrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-08-08 | MoldevHaugesundEliteserien · Norway | 5–4 | Eliteserien · Norway |
| 2021-08-08 | Oud-Heverlee LeuvenvCharleroiPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-08-08 | CangzhouvShenzhenSuper League · China | 2–1 | Super League · China |
| 2021-08-08 | Godoy CruzvRiver PlateLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-08-08 | DundalkvSt. PatricksPremier Division · Ireland | 1–4 | Premier Division · Ireland |
| 2021-08-08 | RennesvLensLigue 1 · France | 1–1 | Ligue 1 · France |