| 2021-12-11 | Dundee UnitedvLivingstonPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-12-11 | StokevMiddlesbroughChampionship · England | 0–0 | Championship · England |
| 2021-12-11 | Fleetwood TownvGillinghamLeague One · England | 2–1 | League One · England |
| 2021-12-11 | MansfieldvSalfordLeague Two · England | 2–1 | League Two · England |
| 2021-12-11 | FalkirkvCove RangersLeague One · Scotland | 0–3 | League One · Scotland |
| 2021-12-11 | Bayern MunichvMainzBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-12-11 | Kings LynnvDover AthleticNational League · England | 2–1 | National League · England |
| 2021-12-11 | AntalyasporvTrabzonsporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-12-11 | HeerenveenvSparta RotterdamEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-12-11 | PordenonevCosenzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-12-11 | Sp LisbonvBoavistaPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-12-11 | HartlepoolvScunthorpeLeague Two · England | 0–0 | League Two · England |
| 2021-12-11 | Man CityvWolvesPremier League · England | 1–0 | Premier League · England |
| 2021-12-11 | DunfermlinevQueen of SthChampionship · Scotland | 3–3 | Championship · Scotland |
| 2021-12-11 | WokingvBoreham WoodNational League · England | 0–2 | National League · England |
| 2021-12-11 | ExetervTranmereLeague Two · England | 0–1 | League Two · England |
| 2021-12-11 | DerbyvBlackpoolChampionship · England | 1–0 | Championship · England |
| 2021-12-11 | WalsallvColchesterLeague Two · England | 3–0 | League Two · England |
| 2021-12-11 | ZwollevFor SittardEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-12-11 | Racing ClubvGodoy CruzLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-12-11 | Notts CountyvSouthendNational League · England | 4–1 | National League · England |
| 2021-12-11 | Rosario CentralvHuracanLiga Profesional · Argentina | 1–4 | Liga Profesional · Argentina |
| 2021-12-11 | EupenvBeerschot VAPro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-12-11 | HuddersfieldvCoventryChampionship · England | 1–1 | Championship · England |
| 2021-12-11 | BochumvDortmundBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-12-11 | TenerifevLugoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-12-11 | CrewevSheffield WedsLeague One · England | 0–2 | League One · England |
| 2021-12-11 | FC VoluntarivUniv. CraiovaSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-12-11 | Krylya SovetovvRubin KazanPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-12-11 | ReimsvSt EtienneLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-12-11 | ArsenalvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2021-12-11 | WolfsburgvStuttgartBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2021-12-11 | BuyuksehyrvKasimpasaSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-12-11 | SalzburgvTirolBundesliga · Austria | 5–0 | Bundesliga · Austria |
| 2021-12-11 | PaderbornvDarmstadt2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-12-11 | AlmeriavZaragozaLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2021-12-11 | KortrijkvOud-Heverlee LeuvenPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-12-11 | MortonvInverness CChampionship · Scotland | 1–6 | Championship · Scotland |
| 2021-12-11 | West BromvReadingChampionship · England | 1–0 | Championship · England |
| 2021-12-11 | St. GallenvLuganoSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-12-11 | FreiburgvHoffenheimBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-12-11 | Holstein KielvSandhausen2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-12-11 | CaenvGuingampLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-12-11 | HartbergvWolfsberger ACBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2021-12-11 | St MirrenvHibernianPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-12-11 | PanetolikosvIonikosSuper League · Greece | 2–2 | Super League · Greece |
| 2021-12-11 |  Egyptv JordanArab Cup | 3–1 | Arab Cup |
| 2021-12-11 | KaragumrukvKonyasporSüper Lig · Turkey | 1–4 | Süper Lig · Turkey |
| 2021-12-11 | IbizavGironaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-12-11 | Ath BilbaovSevillaLa Liga · Spain | 0–1 | La Liga · Spain |