| 2021-08-10 | PachucavAtlasLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-08-09 | San Jose EarthquakesvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2021-08-09 | Yokohama FCvNagoya GrampusJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-08-09 | Shanghai PortvWuhan FCSuper League · China | 3–0 | Super League · China |
| 2021-08-09 | Oita TrinitavKawasaki FrontaleJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-08-09 | Gil VicentevBoavistaPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2021-08-09 | TokushimavGamba OsakaJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-08-09 | Vissel KobevKashiwa ReysolJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-08-09 | SochivUralPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-08-09 | Farul ConstantavSepsi Sf. GheorgheSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-08-09 | Hokkaido Consadole SapporovUrawa RedsJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-08-09 | NordsjaellandvOdenseSuperliga · Denmark | 3–1 | Superliga · Denmark |
| 2021-08-09 | DC UnitedvCF MontrealMLS · United States | 2–1 | MLS · United States |
| 2021-08-09 | Sagan TosuvFC TokyoJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-08-09 | Los Angeles GalaxyvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2021-08-09 | Tianjin Jinmen TigervBeijing GuoanSuper League · China | 3–1 | Super League · China |
| 2021-08-09 | Cerezo OsakavVegalta SendaiJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-08-09 | NorrkopingvKalmarAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-08-09 | Dalian ProvShanghai ShenhuaSuper League · China | 2–4 | Super League · China |
| 2021-08-09 | Shonan BellmarevKashima AntlersJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-08-09 | Shimizu S-PulsevYokohama F. MarinosJ1 League · Japan | 2–2 | J1 League · Japan |
| 2021-08-09 | Avispa FukuokavSanfrecce HiroshimaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-08-09 | IndependientevRacing ClubLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-08-09 | Changchun YataivHebeiSuper League · China | 3–0 | Super League · China |
| 2021-08-09 | VarbergvSiriusAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-08-09 | Arsenal SarandivPatronatoLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2021-08-09 | Wisla PlockvRadomiak RadomEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-08-09 | AldosivivDefensa y JusticiaLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-08-09 | Univ. CraiovavFC VoluntariSuperliga · Romania | 3–0 | Superliga · Romania |
| 2021-08-08 | Shamrock RoversvLongfordPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2021-08-08 | SandefjordvLillestromEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-08-08 | America MGvFluminenseSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-08-08 | Columbus CrewvAtlanta UtdMLS · United States | 2–3 | MLS · United States |
| 2021-08-08 | Slask WroclawvLechia GdanskEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-08-08 | AalborgvAarhusSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-08-08 | Toronto FCvNew York CityMLS · United States | 2–2 | MLS · United States |
| 2021-08-08 | FCSBvGaz Metan MediasSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-08-08 | Randers FCvSonderjyskeSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2021-08-08 | ElfsborgvDegerforsAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2021-08-08 | FC DallasvAustin FCMLS · United States | 2–0 | MLS · United States |
| 2021-08-08 | CearavAtletico GOSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-08-08 | StrasbourgvAngersLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-08-08 | St JohnstonevMotherwellPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-08-08 | StandardvAntwerpPro League · Belgium | 2–5 | Pro League · Belgium |
| 2021-08-08 | MjondalenvTromsoEliteserien · Norway | 2–3 | Eliteserien · Norway |
| 2021-08-08 | HonkavIlvesVeikkausliiga · Finland | 4–1 | Veikkausliiga · Finland |
| 2021-08-08 | Gimnasia L.P.vAtl. TucumanLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-08-08 | NicevReimsLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-08-08 | SK RapidvWolfsberger ACBundesliga · Austria | 3–0 | Bundesliga · Austria |
| 2021-08-08 | FC CincinnativOrlando CityMLS · United States | 1–1 | MLS · United States |