| 2021-08-14 | SwanseavSheffield UnitedChampionship · England | 0–0 | Championship · England |
| 2021-08-14 | Paris SGvStrasbourgLigue 1 · France | 4–2 | Ligue 1 · France |
| 2021-08-14 | BirminghamvStokeChampionship · England | 0–0 | Championship · England |
| 2021-08-14 | FK RostovvCSKA MoscowPremier League · Russia | 1–3 | Premier League · Russia |
| 2021-08-14 | PlymouthvGillinghamLeague One · England | 1–0 | League One · England |
| 2021-08-14 | UTA AradvUniv. CraiovaSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-08-14 | Cove RangersvEast FifeLeague One · Scotland | 5–2 | League One · Scotland |
| 2021-08-14 | AdmiravSalzburgBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-08-14 | AugsburgvHoffenheimBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2021-08-14 | Milton Keynes DonsvSunderlandLeague One · England | 1–2 | League One · England |
| 2021-08-14 | MiddlesbroughvBristol CityChampionship · England | 2–1 | Championship · England |
| 2021-08-14 | For SittardvTwenteEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-08-14 | BenficavAroucaPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-08-13 | Schalke 04vErzgebirge Aue2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-08-13 | LahtivHakaVeikkausliiga · Finland | 0–2 | Veikkausliiga · Finland |
| 2021-08-13 | Shimizu S-PulsevGamba OsakaJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-08-13 | BrentfordvArsenalPremier League · England | 2–0 | Premier League · England |
| 2021-08-13 | M'gladbachvBayern MunichBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-08-13 | HuescavEibarLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-08-13 | EstorilvGuimaraesPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-08-13 | BrondbyvNordsjaellandSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2021-08-13 | Atl. San LuisvNecaxaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-08-13 | SonderjyskevMidtjyllandSuperliga · Denmark | 0–2 | Superliga · Denmark |
| 2021-08-13 | CFR ClujvFarul ConstantaSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-08-13 | ValenciavGetafeLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-08-13 | ViborgvRanders FCSuperliga · Denmark | 1–2 | Superliga · Denmark |
| 2021-08-13 | Lorientv MonacoLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-08-13 | Termalica B-B.vLech PoznanEkstraklasa · Poland | 1–3 | Ekstraklasa · Poland |
| 2021-08-13 | Stal MielecvWislaEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-08-13 | Go Ahead EaglesvHeerenveenEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-08-13 | Edinburgh CityvStenhousemuirLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-08-13 | CharleroivAntwerpPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-08-13 | St. PatricksvWaterfordPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-08-13 | ZaragozavIbizaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-08-13 | St PaulivHamburg2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-08-13 | BesiktasvRizesporSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2021-08-13 | Colon Santa FEvGimnasia L.P.Liga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-08-13 | FC VoluntarivAcademica ClinceniSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-08-12 | Wuhan FCvDalian ProSuper League · China | 2–1 | Super League · China |
| 2021-08-12 | Yokohama F. MarinosvNagoya GrampusJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-08-12 | Shanghai ShenhuavTianjin Jinmen TigerSuper League · China | 1–0 | Super League · China |
| 2021-08-12 | HebeivShanghai PortSuper League · China | 1–0 | Super League · China |
| 2021-08-12 | Beijing GuoanvChangchun YataiSuper League · China | 2–1 | Super League · China |
| 2021-08-11 | ShenzhenvChongqing Liangjiang AthleticSuper League · China | 2–1 | Super League · China |
| 2021-08-11 | Henan Songshan LongmenvGuangzhou CitySuper League · China | 1–1 | Super League · China |
| 2021-08-11 | BastiavNancyLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-08-11 | Guangzhou FCvQingdao FCSuper League · China | 5–0 | Super League · China |
| 2021-08-11 | Shandong TaishanvCangzhouSuper League · China | 2–1 | Super League · China |
| 2021-08-10 | GremiovChapecoense-SCSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-08-10 | Central CordobavEstudiantes L.P.Liga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |