| 2021-08-14 | Lechia GdanskvCracoviaEkstraklasa · Poland | 3–0 | Ekstraklasa · Poland |
| 2021-08-14 | AccringtonvCambridgeLeague One · England | 2–1 | League One · England |
| 2021-08-14 | GironavAmorebietaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-08-14 | SalfordvSuttonLeague Two · England | 0–0 | League Two · England |
| 2021-08-14 | Urawa RedsvSagan TosuJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-08-14 | West BromvLutonChampionship · England | 3–2 | Championship · England |
| 2021-08-14 | UNAM PumasvQueretaroLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-08-14 | OsasunavEspanolLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-08-14 | HeraclesvPSV EindhovenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-08-14 | GuingampvAmiensLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-08-14 | Annan AthleticvStirlingLeague Two · Scotland | 3–1 | League Two · Scotland |
| 2021-08-14 | LeicestervWolvesPremier League · England | 1–0 | Premier League · England |
| 2021-08-14 | LillevNiceLigue 1 · France | 0–4 | Ligue 1 · France |
| 2021-08-14 | BielefeldvFreiburgBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-08-14 | ForfarvKelty HeartsLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2021-08-14 | BarnsleyvCoventryChampionship · England | 1–0 | Championship · England |
| 2021-08-14 | Warta PoznanvLegiaEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2021-08-14 | Kashiwa ReysolvKawasaki FrontaleJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-08-14 | DresdenvHannover2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-08-14 | SochauxvDunkerqueLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-08-14 | WatfordvAston VillaPremier League · England | 3–2 | Premier League · England |
| 2021-08-14 | RochdalevScunthorpeLeague Two · England | 0–0 | League Two · England |
| 2021-08-14 | MansfieldvNewport CountyLeague Two · England | 2–1 | League Two · England |
| 2021-08-14 | ElginvAlbion RvsLeague Two · Scotland | 3–0 | League Two · Scotland |
| 2021-08-14 | NiortvGrenobleLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-08-14 | MallorcavBetisLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-08-14 | Wolfsberger ACvTirolBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2021-08-14 | PonferradinavAlcorconLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-08-14 | Sp BragavSp LisbonPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-08-14 | Atletico-MGvPalmeirasSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-08-14 | ReadingvPrestonChampionship · England | 2–1 | Championship · England |
| 2021-08-14 | BradfordvOldhamLeague Two · England | 2–1 | League Two · England |
| 2021-08-14 | Queens ParkvDumbartonLeague One · Scotland | 3–0 | League One · Scotland |
| 2021-08-14 | EvertonvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2021-08-14 | StuttgartvGreuther FurthBundesliga · Germany | 5–1 | Bundesliga · Germany |
| 2021-08-14 | JuarezvClub TijuanaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-14 | CadizvLevanteLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-08-14 | River PlatevVelez SarsfieldLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-08-14 | PueblavTigres UANLLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-14 | BragantinovJuventudeSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-08-14 | KristiansundvStabaekEliteserien · Norway | 5–1 | Eliteserien · Norway |
| 2021-08-14 | AltayvKayserisporSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2021-08-14 | Pari NNvUfaPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-08-14 | RodezvLe HavreLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-08-14 | Argentinos JrsvBanfieldLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-08-14 | OxfordvCharltonLeague One · England | 2–1 | League One · England |
| 2021-08-14 | Hokkaido Consadole SapporovFC TokyoJ1 League · Japan | 3–2 | J1 League · Japan |
| 2021-08-14 | KalmarvHalmstadAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-08-14 | VizelavTondelaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-08-14 | SeraingvOostendePro League · Belgium | 2–3 | Pro League · Belgium |