| 2021-08-14 | NorwichvLiverpoolPremier League · England | 0–3 | Premier League · England |
| 2021-08-14 | LincolnvFleetwood TownLeague One · England | 2–1 | League One · England |
| 2021-08-14 | KaragumrukvGaziantepSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2021-08-14 | HuddersfieldvFulhamChampionship · England | 1–5 | Championship · England |
| 2021-08-14 | BlackpoolvCardiffChampionship · England | 0–2 | Championship · England |
| 2021-08-14 | ToulousevBastiaLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-08-14 | Port ValevTranmereLeague Two · England | 0–0 | League Two · England |
| 2021-08-14 | Union BerlinvLeverkusenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-08-14 | U Craiova 1948vChindia TargovisteSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-08-14 | Malmo FFvGoteborgAllsvenskan · Sweden | 2–3 | Allsvenskan · Sweden |
| 2021-08-14 | HullvQPRChampionship · England | 0–3 | Championship · England |
| 2021-08-14 | ColchestervNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2021-08-14 | SwindonvCarlisleLeague Two · England | 1–2 | League Two · England |
| 2021-08-14 | BurtonvIpswichLeague One · England | 2–1 | League One · England |
| 2021-08-14 | AC OuluvInter TurkuVeikkausliiga · Finland | 2–0 | Veikkausliiga · Finland |
| 2021-08-14 | BurnleyvBrightonPremier League · England | 1–2 | Premier League · England |
| 2021-08-14 | ChelseavCrystal PalacePremier League · England | 3–0 | Premier League · England |
| 2021-08-14 | EupenvSt TruidenPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-08-14 | Quevilly RouenvDijonLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-08-14 | AFC WimbledonvBoltonLeague One · England | 3–3 | League One · England |
| 2021-08-14 | Nott'm ForestvBournemouthChampionship · England | 1–2 | Championship · England |
| 2021-08-14 | Leyton OrientvExeterLeague Two · England | 3–0 | League Two · England |
| 2021-08-14 | NurnbergvFortuna Dusseldorf2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-08-14 | MontrosevPeterheadLeague One · Scotland | 1–0 | League One · Scotland |
| 2021-08-14 | MorecambevShrewsburyLeague One · England | 2–0 | League One · England |
| 2021-08-14 | Sheffield WedsvDoncasterLeague One · England | 2–0 | League One · England |
| 2021-08-14 | Vegalta SendaivYokohama FCJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-08-14 | WolfsburgvBochumBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-08-14 | Sarpsborg 08vStromsgodsetEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2021-08-14 | PeterborovDerbyChampionship · England | 2–1 | Championship · England |
| 2021-08-14 | DortmundvEin FrankfurtBundesliga · Germany | 5–2 | Bundesliga · Germany |
| 2021-08-14 | Sociedad BvLeganesLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-08-14 | WalsallvForest GreenLeague Two · England | 1–3 | League Two · England |
| 2021-08-14 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 0–0 | MLS · United States |
| 2021-08-14 | St. GilloisevKortrijkPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-08-14 | HuracanvUnion de Santa FeLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-08-14 | HataysporvKasimpasaSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-08-14 | Man UnitedvLeedsPremier League · England | 5–1 | Premier League · England |
| 2021-08-14 | BarrowvHartlepoolLeague Two · England | 3–2 | League Two · England |
| 2021-08-14 | ClydevAlloaLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-08-14 | Bristol RvsvStevenageLeague Two · England | 0–2 | League Two · England |
| 2021-08-14 | NimesvPau FCLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-08-14 | Piast GliwicevWisla PlockEkstraklasa · Poland | 4–3 | Ekstraklasa · Poland |
| 2021-08-14 | GenkvOud-Heverlee LeuvenPro League · Belgium | 4–0 | Pro League · Belgium |
| 2021-08-14 | WiganvRotherhamLeague One · England | 1–0 | League One · England |
| 2021-08-14 | Akhmat GroznyvDynamo MoscowPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-08-14 | Holstein KielvRegensburg2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2021-08-14 | Spartak MoscowvUralPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-08-14 | NancyvValenciennesLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-08-14 | MillwallvBlackburnChampionship · England | 1–1 | Championship · England |