| 2021-08-15 | AarhusvFC CopenhagenSuperliga · Denmark | 1–3 | Superliga · Denmark |
| 2021-08-15 | Nagoya GrampusvShonan BellmareJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-08-15 | Werder BremenvPaderborn2. Bundesliga · Germany | 1–4 | 2. Bundesliga · Germany |
| 2021-08-15 | Houston DynamovColorado RapidsMLS · United States | 1–3 | MLS · United States |
| 2021-08-15 | MjallbyvDjurgardenAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2021-08-15 | AltachvSK RapidBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-08-15 | WaregemvClub BruggePro League · Belgium | 0–4 | Pro League · Belgium |
| 2021-08-15 | Wuhan FCvHebeiSuper League · China | 1–1 | Super League · China |
| 2021-08-15 | BahiavAtletico GOSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-08-15 | Kashima AntlersvTokushimaJ1 League · Japan | 3–0 | J1 League · Japan |
| 2021-08-15 | DroghedavShamrock RoversPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-08-15 | DegerforsvHackenAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2021-08-15 | AngersvLyonLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-08-15 | Beijing GuoanvShanghai ShenhuaSuper League · China | 4–2 | Super League · China |
| 2021-08-15 | Toronto FCvNew England RevolutionMLS · United States | 1–2 | MLS · United States |
| 2021-08-15 | Sepsi Sf. GheorghevFC ArgesSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-08-15 | NewcastlevWest HamPremier League · England | 2–4 | Premier League · England |
| 2021-08-15 | ZwollevVitesseEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-08-15 | CorinthiansvCearaSerie A · Brazil | 3–1 | Serie A · Brazil |
| 2021-08-15 | FC Rapid BucurestivFCSBSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-08-15 | OdensevSilkeborgSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-08-15 | BarcelonavSociedadLa Liga · Spain | 4–2 | La Liga · Spain |
| 2021-08-15 | BohemiansvSligo RoversPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2021-08-15 | FortalezavSantosSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-08-15 | OstersundsvNorrkopingAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-08-15 | ClermontvTroyesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-08-15 | Austria ViennavA. KlagenfurtBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-08-15 | TottenhamvMan CityPremier League · England | 1–0 | Premier League · England |
| 2021-08-15 | Ad. DemirsporvFenerbahceSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-08-15 | BuyuksehyrvAlanyasporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-08-15 | Las PalmasvValladolidLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-08-15 | LASKvSturm GrazBundesliga · Austria | 1–3 | Bundesliga · Austria |
| 2021-08-15 | Cruz AzulvTolucaLiga MX · Mexico | 4–0 | Liga MX · Mexico |
| 2021-08-15 | MonterreyvPachucaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-08-15 | TromsovValerengaEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-08-15 | LensvSt EtienneLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-08-15 | AntalyasporvGoztepSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-08-15 | Chicago FirevColumbus CrewMLS · United States | 1–0 | MLS · United States |
| 2021-08-15 | Rubin KazanvKrylya SovetovPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-08-14 | AlavesvReal MadridLa Liga · Spain | 1–4 | La Liga · Spain |
| 2021-08-14 | SandhausenvKarlsruhe2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-08-14 | Airdrie UtdvFalkirkLeague One · Scotland | 1–2 | League One · Scotland |
| 2021-08-14 | Minnesota UnitedvLos Angeles GalaxyMLS · United States | 0–1 | MLS · United States |
| 2021-08-14 | HartbergvRiedBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-08-14 | CheltenhamvWycombeLeague One · England | 1–3 | League One · England |
| 2021-08-14 | LongfordvFinn HarpsPremier Division · Ireland | 0–3 | Premier Division · Ireland |
| 2021-08-14 | Atl. TucumanvAldosiviLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2021-08-14 | PortsmouthvCreweLeague One · England | 2–0 | League One · England |
| 2021-08-14 | WaalwijkvAZ AlkmaarEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-08-14 | AjaxvNijmegenEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |