| 2021-08-15 | OviedovLugoLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2021-08-15 | Cercle BruggevAnderlechtPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-08-15 | MjondalenvRosenborgEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2021-08-15 | CF MontrealvNew York Red BullsMLS · United States | 2–1 | MLS · United States |
| 2021-08-15 | Changchun YataivDalian ProSuper League · China | 3–1 | Super League · China |
| 2021-08-15 | CuiabavAthletico-PRSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-08-15 | LillestromvBodo/GlimtEliteserien · Norway | 0–1 | Eliteserien · Norway |
| 2021-08-15 | FamalicaovPortoPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-08-15 | HJKvMariehamnVeikkausliiga · Finland | 1–0 | Veikkausliiga · Finland |
| 2021-08-15 | CeltavAth MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-08-15 | AtlasvClub AmericaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-08-15 | FC DallasvSporting Kansas CityMLS · United States | 0–2 | MLS · United States |
| 2021-08-15 | KrasnodarvArsenal TulaPremier League · Russia | 3–2 | Premier League · Russia |
| 2021-08-15 | Sp GijonvBurgosLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-08-15 | Sao PaulovGremioSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-08-15 | PlatensevArsenal SarandiLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-08-15 | Willem IIvFeyenoordEredivisie · Netherlands | 0–4 | Eredivisie · Netherlands |
| 2021-08-15 | Club LeonvMazatlan FCLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2021-08-15 | MainzvRB LeipzigBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-08-15 | ReimsvMontpellierLigue 1 · France | 3–3 | Ligue 1 · France |
| 2021-08-15 | SevillavVallecanoLa Liga · Spain | 3–0 | La Liga · Spain |
| 2021-08-15 | Shanghai PortvTianjin Jinmen TigerSuper League · China | 5–0 | Super League · China |
| 2021-08-15 | KuPSvKTPVeikkausliiga · Finland | 4–0 | Veikkausliiga · Finland |
| 2021-08-15 | PortimonensevGil VicentePrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-08-15 | Estudiantes L.P.vBoca JuniorsLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-08-15 | Slask WroclawvLecznaEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-08-15 | DarmstadtvIngolstadt2. Bundesliga · Germany | 6–1 | 2. Bundesliga · Germany |
| 2021-08-15 | Avispa FukuokavCerezo OsakaJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-08-15 | PatronatovCentral CordobaLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-08-15 | VikingvMoldeEliteserien · Norway | 3–2 | Eliteserien · Norway |
| 2021-08-15 | MarseillevBordeauxLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-08-15 | FuenlabradavTenerifeLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-08-15 | UtrechtvSparta RotterdamEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2021-08-15 | OddvHaugesundEliteserien · Norway | 4–2 | Eliteserien · Norway |
| 2021-08-15 | Yokohama F. MarinosvOita TrinitaJ1 League · Japan | 5–1 | J1 League · Japan |
| 2021-08-15 | Beerschot VAvStandardPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-08-15 | Rosario CentralvIndependienteLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-08-15 | BrannvSandefjordEliteserien · Norway | 3–2 | Eliteserien · Norway |
| 2021-08-15 | HammarbyvElfsborgAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2021-08-15 | GentvMechelenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-08-15 | Derry CityvDundalkPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2021-08-15 | Santa ClaravMoreirensePrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-08-15 | Flamengo RJvSport RecifeSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-08-15 | Real Salt LakevAustin FCMLS · United States | 1–0 | MLS · United States |
| 2021-08-15 | FC KolnvHerthaBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-08-15 | HeidenheimvHansa Rostock2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-08-15 | Lokomotiv MoscowvZenitPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-08-15 | NantesvMetzLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-08-15 | CambuurvGroningenEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-08-15 | ZaglebievPogon SzczecinEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |