| 2021-08-17 | BurtonvSunderlandLeague One · England | 1–0 | League One · England |
| 2021-08-17 | PlymouthvCambridgeLeague One · England | 1–1 | League One · England |
| 2021-08-17 | ColchestervMansfieldLeague Two · England | 1–1 | League Two · England |
| 2021-08-17 | Defensa y JusticiavSarmiento JuninLiga Profesional · Argentina | 4–2 | Liga Profesional · Argentina |
| 2021-08-17 | SwanseavStokeChampionship · England | 1–3 | Championship · England |
| 2021-08-17 | MillwallvFulhamChampionship · England | 1–2 | Championship · England |
| 2021-08-17 | LanusvGodoy CruzLiga Profesional · Argentina | 3–1 | Liga Profesional · Argentina |
| 2021-08-17 | AFC WimbledonvGillinghamLeague One · England | 1–1 | League One · England |
| 2021-08-17 | Bristol RvsvOldhamLeague Two · England | 1–0 | League Two · England |
| 2021-08-17 | ReadingvBristol CityChampionship · England | 2–3 | Championship · England |
| 2021-08-17 | SwindonvTranmereLeague Two · England | 0–0 | League Two · England |
| 2021-08-17 | RochdalevForest GreenLeague Two · England | 1–2 | League Two · England |
| 2021-08-17 | PortsmouthvShrewsburyLeague One · England | 1–0 | League One · England |
| 2021-08-17 | BarnsleyvLutonChampionship · England | 0–1 | Championship · England |
| 2021-08-17 | BlackpoolvCoventryChampionship · England | 0–1 | Championship · England |
| 2021-08-17 | Sheffield WedsvFleetwood TownLeague One · England | 1–0 | League One · England |
| 2021-08-17 | WalsallvScunthorpeLeague Two · England | 1–1 | League Two · England |
| 2021-08-17 | BradfordvStevenageLeague Two · England | 4–1 | League Two · England |
| 2021-08-17 | OxfordvCreweLeague One · England | 1–0 | League One · England |
| 2021-08-17 | AccringtonvDoncasterLeague One · England | 1–0 | League One · England |
| 2021-08-17 | WiganvWycombeLeague One · England | 1–1 | League One · England |
| 2021-08-17 | Chapecoense-SCvAmerica MGSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-08-17 | Crawley TownvSalfordLeague Two · England | 2–1 | League Two · England |
| 2021-08-16 | SochivKhimkiPremier League · Russia | 3–0 | Premier League · Russia |
| 2021-08-16 | MalagavMirandesLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-08-16 | ElchevAth BilbaoLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-08-16 | Racing ClubvNewells Old BoysLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-08-16 | VarbergvOrebroAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-08-16 | Gaz Metan MediasvFC BotosaniSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-08-16 | SivassporvKonyasporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-08-16 | VillarrealvGranadaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-08-16 | BoavistavPacos FerreiraPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2021-08-16 | JagielloniavGornik Z.Ekstraklasa · Poland | 1–3 | Ekstraklasa · Poland |
| 2021-08-16 | Paris FCvAuxerreLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-08-16 | Din. BucurestivMioveniSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-08-16 | Santos LagunavGuadalajara ChivasLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-08-16 | InternacionalvFluminenseSerie A · Brazil | 4–2 | Serie A · Brazil |
| 2021-08-16 | BelenensesvMaritimoPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-08-16 | VejlevAalborgSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2021-08-16 | Yeni MalatyasporvTrabzonsporSüper Lig · Turkey | 1–5 | Süper Lig · Turkey |
| 2021-08-16 | GiresunsporvGalatasaraySüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2021-08-16 | CartagenavAlmeriaLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2021-08-16 | SJKvHonkaVeikkausliiga · Finland | 3–2 | Veikkausliiga · Finland |
| 2021-08-16 | Nashville SCvDC UnitedMLS · United States | 5–2 | MLS · United States |
| 2021-08-16 | SiriusvAIKAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2021-08-16 | Portland TimbersvSeattle SoundersMLS · United States | 2–6 | MLS · United States |
| 2021-08-16 | Talleres CordobavSan LorenzoLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-08-15 | BrestvRennesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-08-15 | New York CityvInter MiamiMLS · United States | 2–0 | MLS · United States |
| 2021-08-15 | Atlanta UtdvLos Angeles FCMLS · United States | 1–0 | MLS · United States |