| 2021-08-20 | Wisla PlockvZaglebieEkstraklasa · Poland | 4–0 | Ekstraklasa · Poland |
| 2021-08-20 | HakavAC OuluVeikkausliiga · Finland | 0–1 | Veikkausliiga · Finland |
| 2021-08-20 | MidtjyllandvSilkeborgSuperliga · Denmark | 3–0 | Superliga · Denmark |
| 2021-08-20 | Bristol CityvSwanseaChampionship · England | 0–1 | Championship · England |
| 2021-08-20 | Finn HarpsvSt. PatricksPremier Division · Ireland | 3–1 | Premier Division · Ireland |
| 2021-08-20 | ValladolidvZaragozaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-08-20 | BrestvParis SGLigue 1 · France | 2–4 | Ligue 1 · France |
| 2021-08-20 | Sarmiento JuninvAtl. TucumanLiga Profesional · Argentina | 3–0 | Liga Profesional · Argentina |
| 2021-08-20 | AlmeriavOviedoLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-08-20 | StandardvOostendePro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-08-20 | KayserisporvAd. DemirsporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-08-20 | DundalkvDroghedaPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2021-08-20 | AldosivivColon Santa FELiga Profesional · Argentina | 3–0 | Liga Profesional · Argentina |
| 2021-08-20 | BanfieldvEstudiantes L.P.Liga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-19 | Cruz AzulvMonterreyLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-19 | FC CincinnativCF MontrealMLS · United States | 0–0 | MLS · United States |
| 2021-08-19 | Santos LagunavAtlasLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-19 | New England RevolutionvDC UnitedMLS · United States | 3–2 | MLS · United States |
| 2021-08-19 | JuarezvClub AmericaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-08-19 | Atlanta UtdvToronto FCMLS · United States | 1–0 | MLS · United States |
| 2021-08-19 | Nashville SCvOrlando CityMLS · United States | 1–1 | MLS · United States |
| 2021-08-19 | FC DallasvSeattle SoundersMLS · United States | 0–1 | MLS · United States |
| 2021-08-19 | New York Red BullsvColumbus CrewMLS · United States | 1–0 | MLS · United States |
| 2021-08-19 | Sporting Kansas CityvPortland TimbersMLS · United States | 1–1 | MLS · United States |
| 2021-08-19 | Austin FCvVancouver WhitecapsMLS · United States | 1–2 | MLS · United States |
| 2021-08-19 | Philadelphia UnionvNew York CityMLS · United States | 1–0 | MLS · United States |
| 2021-08-19 | Inter MiamivChicago FireMLS · United States | 3–2 | MLS · United States |
| 2021-08-19 | Guadalajara ChivasvClub LeonLiga MX · Mexico | 0–3 | Liga MX · Mexico |
| 2021-08-19 | Real Salt LakevHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2021-08-18 | BirminghamvBournemouthChampionship · England | 0–2 | Championship · England |
| 2021-08-18 | Nott'm ForestvBlackburnChampionship · England | 1–2 | Championship · England |
| 2021-08-18 | HullvDerbyChampionship · England | 0–1 | Championship · England |
| 2021-08-18 | CuiabavGremioSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-08-18 | Tigres UANLvQueretaroLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2021-08-18 | Quevilly RouenvBastiaLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-08-18 | San Jose EarthquakesvMinnesota UnitedMLS · United States | 1–1 | MLS · United States |
| 2021-08-18 | Club TijuanavPueblaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-18 | MiddlesbroughvQPRChampionship · England | 2–3 | Championship · England |
| 2021-08-18 | Los Angeles GalaxyvColorado RapidsMLS · United States | 1–2 | MLS · United States |
| 2021-08-18 | NecaxavUNAM PumasLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2021-08-18 | West BromvSheffield UnitedChampionship · England | 4–0 | Championship · England |
| 2021-08-17 | Port ValevCarlisleLeague Two · England | 0–0 | League Two · England |
| 2021-08-17 | Milton Keynes DonsvCharltonLeague One · England | 2–1 | League One · England |
| 2021-08-17 | MorecambevRotherhamLeague One · England | 0–1 | League One · England |
| 2021-08-17 | HuddersfieldvPrestonChampionship · England | 1–0 | Championship · England |
| 2021-08-17 | BarrowvExeterLeague Two · England | 0–0 | League Two · England |
| 2021-08-17 | CheltenhamvIpswichLeague One · England | 2–1 | League One · England |
| 2021-08-17 | TolucavMazatlan FCLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2021-08-17 | LincolnvBoltonLeague One · England | 0–1 | League One · England |
| 2021-08-17 | PeterborovCardiffChampionship · England | 2–2 | Championship · England |