| 2021-08-21 | FC ArgesvCFR ClujSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-08-21 | Oud-Heverlee LeuvenvEupenPro League · Belgium | 1–4 | Pro League · Belgium |
| 2021-08-21 | Albion RvsvAnnan AthleticLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2021-08-21 | AlcorconvFuenlabradaLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-08-21 | CaenvNancyLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-08-21 | CittadellavVicenzaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-08-21 | Gil VicentevBenficaPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-08-21 | PaderbornvSt Pauli2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-08-21 | LecznavWislaEkstraklasa · Poland | 1–3 | Ekstraklasa · Poland |
| 2021-08-21 | Godoy CruzvHuracanLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-21 | BrightonvWatfordPremier League · England | 2–0 | Premier League · England |
| 2021-08-21 | StabaekvMjondalenEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-08-21 | TranmerevNewport CountyLeague Two · England | 0–1 | League Two · England |
| 2021-08-21 | SolihullvWrexhamNational League · England | 2–2 | National League · England |
| 2021-08-21 | HalifaxvMaidenheadNational League · England | 1–2 | National League · England |
| 2021-08-21 | ArbroathvPartickChampionship · Scotland | 3–1 | Championship · Scotland |
| 2021-08-21 | AldershotvChesterfieldNational League · England | 0–2 | National League · England |
| 2021-08-21 | Sanfrecce HiroshimavKawasaki FrontaleJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-08-21 | GaziantepvBesiktasSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-08-21 | ExetervBristol RvsLeague Two · England | 4–1 | League Two · England |
| 2021-08-21 | WealdstonevWokingNational League · England | 1–2 | National League · England |
| 2021-08-21 | LugovSociedad BLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-08-21 | CardiffvMillwallChampionship · England | 3–1 | Championship · England |
| 2021-08-21 | HerthavWolfsburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-08-21 | TirolvAltachBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2021-08-21 | StockportvDag and RedNational League · England | 1–3 | National League · England |
| 2021-08-21 | Fleetwood TownvCheltenhamLeague One · England | 3–2 | League One · England |
| 2021-08-21 | St TruidenvKortrijkPro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-08-21 | Yokohama F. MarinosvVegalta SendaiJ1 League · Japan | 5–0 | J1 League · Japan |
| 2021-08-21 | IpswichvMilton Keynes DonsLeague One · England | 2–2 | League One · England |
| 2021-08-21 | Central CordobavPlatenseLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2021-08-21 | UfavZenitPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-08-21 | CharltonvWiganLeague One · England | 0–2 | League One · England |
| 2021-08-21 | PSV EindhovenvCambuurEredivisie · Netherlands | 4–1 | Eredivisie · Netherlands |
| 2021-08-21 | WeymouthvBoreham WoodNational League · England | 0–2 | National League · England |
| 2021-08-21 | East FifevMontroseLeague One · Scotland | 0–2 | League One · Scotland |
| 2021-08-21 | CrewevAccringtonLeague One · England | 0–1 | League One · England |
| 2021-08-21 | FalkirkvClydeLeague One · Scotland | 3–0 | League One · Scotland |
| 2021-08-20 | HannovervHeidenheim2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-08-20 | MoreirensevSp BragaPrimeira Liga · Portugal | 2–3 | Primeira Liga · Portugal |
| 2021-08-20 | Fortuna DusseldorfvHolstein Kiel2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-08-20 | AroucavFamalicaoPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-08-20 | BetisvCadizLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-08-20 | RB LeipzigvStuttgartBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-08-20 | FrosinonevParmaSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-08-20 | NijmegenvZwolleEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-08-20 | Radomiak RadomvWarta PoznanEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-08-20 | WaterfordvLongfordPremier Division · Ireland | 4–1 | Premier Division · Ireland |
| 2021-08-20 | Chindia TargovistevAcademica ClinceniSuperliga · Romania | 2–2 | Superliga · Romania |
| 2021-08-20 | Farul ConstantavDin. BucurestiSuperliga · Romania | 3–0 | Superliga · Romania |