| 2010-03-23 | West HamvWolvesPremier League · England | 1–3 | Premier League · England |
| 2010-03-23 | Bristol CityvBarnsleyChampionship · England | 5–3 | Championship · England |
| 2010-03-23 | BresciavCesenaSerie B · Italy | 0–1 | Serie B · Italy |
| 2010-03-23 | SassuolovAlbinoleffeSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-03-23 | PiacenzavCittadellaSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-03-23 | PeterheadvEast FifeLeague One · Scotland | 3–1 | League One · Scotland |
| 2010-03-23 | MansfieldvAltrinchamNational League · England | 1–1 | National League · England |
| 2010-03-23 | TorinovAscoliSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-03-23 | PadovavGrossetoSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-03-23 | SalernitanavLecceSerie B · Italy | 1–2 | Serie B · Italy |
| 2010-03-23 | ScunthorpevPeterboroChampionship · England | 4–0 | Championship · England |
| 2010-03-23 | QPRvDerbyChampionship · England | 1–1 | Championship · England |
| 2010-03-23 | ElginvMontroseLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2010-03-23 | MortonvRaith RvsChampionship · Scotland | 1–1 | Championship · Scotland |
| 2010-03-23 | BlackpoolvSwanseaChampionship · England | 5–1 | Championship · England |
| 2010-03-23 | KidderminstervYorkNational League · England | 0–1 | National League · England |
| 2010-03-23 | ColchestervBrentfordLeague One · England | 3–3 | League One · England |
| 2010-03-23 | SouthendvWalsallLeague One · England | 3–0 | League One · England |
| 2010-03-23 | MiddlesbroughvPrestonChampionship · England | 2–0 | Championship · England |
| 2010-03-23 | IpswichvPlymouthChampionship · England | 0–2 | Championship · England |
| 2010-03-23 | GallipolivTriestinaSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-03-23 | AccringtonvBurtonLeague Two · England | 0–2 | League Two · England |
| 2010-03-23 | SevillavXerezLa Liga · Spain | 1–1 | La Liga · Spain |
| 2010-03-23 | DumbartonvStenhousemuirLeague One · Scotland | 2–1 | League One · Scotland |
| 2010-03-23 | RotherhamvMacclesfieldLeague Two · England | 3–1 | League Two · England |
| 2010-03-23 | GraysvStevenageNational League · England | 1–2 | National League · England |
| 2010-03-23 | AFC WimbledonvBarrowNational League · England | 0–2 | National League · England |
| 2010-03-22 | Fortuna DusseldorfvKaiserslautern2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2010-03-22 | AngersvCaenLigue 2 · France | 2–2 | Ligue 2 · France |
| 2010-03-22 | BetisvCastellonLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2010-03-22 | LeedsvMillwallLeague One · England | 0–2 | League One · England |
| 2010-03-22 | BursasporvDenizlisporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2010-03-21 | PAOKvAEKSuper League · Greece | 0–1 | Super League · Greece |
| 2010-03-21 | SociedadvLevanteLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2010-03-21 | GerminalvClub BruggePro League · Belgium | 1–4 | Pro League · Belgium |
| 2010-03-21 | Cercle BruggevSt TruidenPro League · Belgium | 3–1 | Pro League · Belgium |
| 2010-03-21 | PanathinaikosvOlympiakosSuper League · Greece | 0–1 | Super League · Greece |
| 2010-03-21 | BarivParmaSerie A · Italy | 1–1 | Serie A · Italy |
| 2010-03-21 | MallorcavAth MadridLa Liga · Spain | 4–1 | La Liga · Spain |
| 2010-03-21 | HamburgvSchalke 04Bundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2010-03-21 | LokerenvAnderlechtPro League · Belgium | 0–4 | Pro League · Belgium |
| 2010-03-21 | TrabzonsporvGalatasaraySüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2010-03-21 | Man UnitedvLiverpoolPremier League · England | 2–1 | Premier League · England |
| 2010-03-21 | OsasunavSantanderLa Liga · Spain | 1–3 | La Liga · Spain |
| 2010-03-21 | PanioniosvArisSuper League · Greece | 1–1 | Super League · Greece |
| 2010-03-21 | SpartavAZ AlkmaarEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2010-03-21 | KavalavLarisaSuper League · Greece | 3–3 | Super League · Greece |
| 2010-03-21 | BordeauxvLilleLigue 1 · France | 3–1 | Ligue 1 · France |
| 2010-03-21 | ChievovCataniaSerie A · Italy | 1–1 | Serie A · Italy |
| 2010-03-21 | Den HaagvVVV VenloEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |