| 2021-12-11 | Union de Santa FevColon Santa FELiga Profesional · Argentina | 3–0 | Liga Profesional · Argentina |
| 2021-12-11 | MaidenheadvSolihullNational League · England | 0–4 | National League · England |
| 2021-12-11 | ZaglebievWislaEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-12-11 | MaritimovSanta ClaraPrimeira Liga · Portugal | 4–1 | Primeira Liga · Portugal |
| 2021-12-11 | SunderlandvPlymouthLeague One · England | 2–1 | League One · England |
| 2021-12-11 | CharltonvCambridgeLeague One · England | 2–0 | League One · England |
| 2021-12-11 | PortsmouthvMorecambeLeague One · England | 2–0 | League One · England |
| 2021-12-11 | St JohnstonevAberdeenPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-12-11 | HullvBristol CityChampionship · England | 2–2 | Championship · England |
| 2021-12-11 | HerthavBielefeldBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-12-11 | GuimaraesvTondelaPrimeira Liga · Portugal | 5–2 | Primeira Liga · Portugal |
| 2021-12-11 | NimesvNancyLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-12-11 | FiorentinavSalernitanaSerie A · Italy | 4–0 | Serie A · Italy |
| 2021-12-11 | UTA AradvFC BotosaniSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-12-11 | BirminghamvCardiffChampionship · England | 2–2 | Championship · England |
| 2021-12-11 | BarrowvSwindonLeague Two · England | 2–0 | League Two · England |
| 2021-12-11 | WycombevAFC WimbledonLeague One · England | 2–2 | League One · England |
| 2021-12-11 | Fortuna DusseldorfvSt Pauli2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-12-11 | FK RostovvUralPremier League · Russia | 1–4 | Premier League · Russia |
| 2021-12-11 | RB LeipzigvM'gladbachBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2021-12-11 | EibarvMalagaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2021-12-11 | DunkerquevAuxerreLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-12-11 | GrimsbyvChesterfieldNational League · England | 0–1 | National League · England |
| 2021-12-11 | Estudiantes L.P.vAldosiviLiga Profesional · Argentina | 2–3 | Liga Profesional · Argentina |
| 2021-12-11 | ValenciennesvParis FCLigue 2 · France | 1–4 | Ligue 2 · France |
| 2021-12-11 | StevenagevCarlisleLeague Two · England | 0–2 | League Two · England |
| 2021-12-11 | Radomiak RadomvLech PoznanEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-12-11 | Lechia GdanskvJagielloniaEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-12-11 |  Timor-Lestev PhilippinesAFF Championship | 0–7 | AFF Championship |
| 2021-12-11 | AlavesvGetafeLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-12-11 | HelsingborgvHalmstadAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2021-12-11 | Leyton OrientvCrawley TownLeague Two · England | 1–2 | League Two · England |
| 2021-12-11 | AlloavClydeLeague One · Scotland | 0–1 | League One · Scotland |
| 2021-12-11 | RizesporvGoztepSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-12-11 | Milton Keynes DonsvOxfordLeague One · England | 1–2 | League One · England |
| 2021-12-11 | GianninavVolos NFCSuper League · Greece | 3–2 | Super League · Greece |
| 2021-12-11 | DijonvNiortLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-12-11 | LausannevZurichSuper League · Switzerland | 1–3 | Super League · Switzerland |
| 2021-12-11 | WealdstonevHalifaxNational League · England | 0–1 | National League · England |
| 2021-12-11 | IngolstadtvHannover2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-12-11 | AccringtonvBoltonLeague One · England | 1–0 | League One · England |
| 2021-12-11 | PeterheadvEast FifeLeague One · Scotland | 1–1 | League One · Scotland |
| 2021-12-11 |  El Salvadorv ChileFriendly | 0–1 | Friendly |
| 2021-12-11 | PatronatovGimnasia L.P.Liga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-12-11 | CheltenhamvLincolnLeague One · England | 2–2 | League One · England |
| 2021-12-11 | HarrogatevNorthamptonLeague Two · England | 1–2 | League Two · England |
| 2021-12-11 | UtrechtvGo Ahead EaglesEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-12-11 | RotherhamvBurtonLeague One · England | 3–1 | League One · England |
| 2021-12-11 | Bristol RvsvRochdaleLeague Two · England | 4–2 | League Two · England |
| 2021-12-11 | NorwichvMan UnitedPremier League · England | 0–1 | Premier League · England |