| 2021-08-22 | TondelavPortimonensePrimeira Liga · Portugal | 0–3 | Primeira Liga · Portugal |
| 2021-08-22 | LASKvHartbergBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-08-22 | NapolivVeneziaSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-08-22 | PalmeirasvCuiabaSerie A · Brazil | 0–2 | Serie A · Brazil |
| 2021-08-22 | SouthamptonvMan UnitedPremier League · England | 1–1 | Premier League · England |
| 2021-08-22 | Erzgebirge AuevSandhausen2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2021-08-22 | MetzvReimsLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-08-22 | Ath MadridvElcheLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-08-22 | Union de Santa FevTalleres CordobaLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-08-22 | SantosvInternacionalSerie A · Brazil | 2–2 | Serie A · Brazil |
| 2021-08-22 | DC UnitedvAtlanta UtdMLS · United States | 1–2 | MLS · United States |
| 2021-08-22 | ViborgvAarhusSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-08-22 | Piast GliwicevSlask WroclawEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-08-22 | Sturm GrazvAustria ViennaBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2021-08-22 | Colorado RapidsvReal Salt LakeMLS · United States | 2–1 | MLS · United States |
| 2021-08-22 | TwentevAjaxEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-08-22 | Bayern MunichvFC KolnBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2021-08-22 | RomavFiorentinaSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-08-22 | GoztepvYeni MalatyasporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-08-22 | CremonesevLecceSerie B · Italy | 3–0 | Serie B · Italy |
| 2021-08-22 | MechelenvSt. GilloisePro League · Belgium | 3–1 | Pro League · Belgium |
| 2021-08-22 | Vancouver WhitecapsvLos Angeles FCMLS · United States | 2–1 | MLS · United States |
| 2021-08-22 | Lech PoznanvLechia GdanskEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-08-22 | Pari NNvFK RostovPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-08-22 | HIFKvKuPSVeikkausliiga · Finland | 1–5 | Veikkausliiga · Finland |
| 2021-08-22 | CrotonevComoSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-08-22 |  Nigerv SudanFriendly | 2–1 | Friendly |
| 2021-08-22 | New England RevolutionvFC CincinnatiMLS · United States | 4–1 | MLS · United States |
| 2021-08-22 | Athletico-PRvCorinthiansSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-08-22 | TernanavBresciaSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-08-22 | LausannevBaselSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2021-08-22 | FC CopenhagenvSonderjyskeSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-08-22 | IbizavMalagaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2021-08-21 | Crystal PalacevBrentfordPremier League · England | 0–0 | Premier League · England |
| 2021-08-21 | TorquayvAltrinchamNational League · England | 1–3 | National League · England |
| 2021-08-21 | GremiovBahiaSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-08-21 | GrenoblevQuevilly RouenLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-08-21 | PordenonevPerugiaSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-08-21 | Hansa RostockvDresden2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2021-08-21 | Oita TrinitavHokkaido Consadole SapporoJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-08-21 | HarrogatevBarrowLeague Two · England | 2–1 | League Two · England |
| 2021-08-21 | RizesporvKaragumrukSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-08-21 | PrestonvPeterboroChampionship · England | 1–0 | Championship · England |
| 2021-08-21 | CarlislevLeyton OrientLeague Two · England | 1–1 | League Two · England |
| 2021-08-21 | SunderlandvAFC WimbledonLeague One · England | 1–0 | League One · England |
| 2021-08-21 | EspanolvVillarrealLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-08-21 | WycombevLincolnLeague One · England | 1–0 | League One · England |
| 2021-08-21 | LeverkusenvM'gladbachBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-08-21 | ScunthorpevSuttonLeague Two · England | 1–1 | League Two · England |
| 2021-08-21 | Pau FCvBastiaLigue 2 · France | 2–0 | Ligue 2 · France |