| 2021-08-22 | RennesvNantesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-08-22 | ValerengavVikingEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-08-22 | GironavLas PalmasLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-08-22 | RegginavMonzaSerie B · Italy | 0–0 | Serie B · Italy |
| 2021-08-22 | LyonvClermontLigue 1 · France | 3–3 | Ligue 1 · France |
| 2021-08-22 | HeartsvAberdeenPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-08-22 | StrasbourgvTroyesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-08-22 | PisavSpalSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-08-22 | GuimaraesvVizelaPrimeira Liga · Portugal | 4–0 | Primeira Liga · Portugal |
| 2021-08-22 | KonyasporvBuyuksehyrSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-08-22 | Philadelphia UnionvCF MontrealMLS · United States | 1–1 | MLS · United States |
| 2021-08-22 | AscolivCosenzaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-08-22 | AIKvHackenAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2021-08-22 | St JohnstonevDundee UnitedPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-08-22 | SociedadvVallecanoLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-08-22 | IngolstadtvNurnberg2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-08-22 | MaritimovPortoPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-08-22 | EibarvPonferradinaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-08-22 | BordeauxvAngersLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-08-22 | Newells Old BoysvRosario CentralLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-22 | Austin FCvPortland TimbersMLS · United States | 3–1 | MLS · United States |
| 2021-08-22 | ArsenalvChelseaPremier League · England | 0–2 | Premier League · England |
| 2021-08-22 | OrebrovSiriusAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-08-22 | ServettevLuzernSuper League · Switzerland | 4–1 | Super League · Switzerland |
| 2021-08-22 | Boca JuniorsvPatronatoLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-08-22 | San LorenzovArgentinos JrsLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-08-22 | Nagoya GrampusvAvispa FukuokaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-08-22 | LevantevReal MadridLa Liga · Spain | 3–3 | La Liga · Spain |
| 2021-08-22 | HuescavCartagenaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-08-22 | MontpelliervLorientLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-08-22 | BolognavSalernitanaSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-08-22 | HaugesundvLillestromEliteserien · Norway | 0–3 | Eliteserien · Norway |
| 2021-08-22 | Club AmericavClub TijuanaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-08-22 | WolvesvTottenhamPremier League · England | 0–1 | Premier League · England |
| 2021-08-22 | FC BotosanivFC Rapid BucurestiSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-08-22 | Atl. San LuisvCruz AzulLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-08-22 | Ross CountyvRangersPremiership · Scotland | 2–4 | Premiership · Scotland |
| 2021-08-22 | RosenborgvOddEliteserien · Norway | 5–0 | Eliteserien · Norway |
| 2021-08-22 | Club BruggevBeerschot VAPro League · Belgium | 3–2 | Pro League · Belgium |
| 2021-08-22 | Inter MiamivToronto FCMLS · United States | 3–1 | MLS · United States |
| 2021-08-22 | UTA AradvFC VoluntariSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-08-22 | Houston DynamovFC DallasMLS · United States | 2–2 | MLS · United States |
| 2021-08-22 | ElfsborgvHammarbyAllsvenskan · Sweden | 2–2 | Allsvenskan · Sweden |
| 2021-08-22 | SandefjordvTromsoEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-08-22 | HoffenheimvUnion BerlinBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-08-22 | Club LeonvSantos LagunaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-08-22 | VitessevWillem IIEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2021-08-22 | BeneventovAlessandriaSerie B · Italy | 4–3 | Serie B · Italy |
| 2021-08-22 | KhimkivRubin KazanPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-08-22 | UdinesevJuventusSerie A · Italy | 2–2 | Serie A · Italy |