| 2021-08-25 | HuracanvVelez SarsfieldLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-25 | Cerezo OsakavShonan BellmareJ1 League · Japan | 1–5 | J1 League · Japan |
| 2021-08-25 | Vegalta SendaivFC TokyoJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-08-25 | Hokkaido Consadole SapporovNagoya GrampusJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-08-25 | Oita TrinitavVissel KobeJ1 League · Japan | 1–3 | J1 League · Japan |
| 2021-08-24 | Leyton OrientvHarrogateLeague Two · England | 0–2 | League Two · England |
| 2021-08-24 | PatronatovBanfieldLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-24 | America MGvBragantinoSerie A · Brazil | 0–2 | Serie A · Brazil |
| 2021-08-24 | Atl. TucumanvIndependienteLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-08-24 | Colon Santa FEvSarmiento JuninLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-24 | FluminensevAtletico-MGSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-08-23 | QueretarovPachucaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-08-23 | West HamvLeicesterPremier League · England | 4–1 | Premier League · England |
| 2021-08-23 | GetafevSevillaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-08-23 | Sport RecifevSao PauloSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-08-23 | LahtivHJKVeikkausliiga · Finland | 0–1 | Veikkausliiga · Finland |
| 2021-08-23 | Pacos FerreiravEstorilPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2021-08-23 | BoavistavSanta ClaraPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-08-23 | AuxerrevGuingampLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-08-23 | CagliarivSpeziaSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-08-23 | MiovenivU Craiova 1948Superliga · Romania | 1–0 | Superliga · Romania |
| 2021-08-23 | OstersundsvKalmarAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2021-08-23 | TrabzonsporvSivassporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-08-23 | LeganesvBurgosLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-08-23 | DjurgardenvMjallbyAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-08-23 | Gimnasia L.P.vRiver PlateLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-08-23 | SampdoriavMilanSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-08-23 | MirandesvAmorebietaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-08-23 | FCSBvSepsi Sf. GheorgheSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-08-23 | NecaxavJuarezLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-08-23 | GalatasarayvHataysporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-08-23 | NordsjaellandvVejleSuperliga · Denmark | 3–1 | Superliga · Denmark |
| 2021-08-23 | GoteborgvVarbergAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-08-23 | OsasunavCeltaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-08-22 | DundeevHibernianPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2021-08-22 | FenerbahcevAntalyasporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-08-22 | HalmstadvNorrkopingAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2021-08-22 | Lokomotiv MoscowvKrasnodarPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-08-22 | Orlando CityvChicago FireMLS · United States | 1–0 | MLS · United States |
| 2021-08-22 | MariehamnvHonkaVeikkausliiga · Finland | 1–3 | Veikkausliiga · Finland |
| 2021-08-22 | FeyenoordvGo Ahead EaglesEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-08-22 | Randers FCvAalborgSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-08-22 | HamburgvDarmstadt2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-08-22 | JuventudevFortalezaSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-08-22 | UNAM PumasvPueblaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-08-22 | MonterreyvGuadalajara ChivasLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-08-22 | WaregemvCharleroiPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-08-22 | SK RapidvRiedBundesliga · Austria | 3–0 | Bundesliga · Austria |
| 2021-08-22 | CearavFlamengo RJSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-08-22 | Bodo/GlimtvKristiansundEliteserien · Norway | 3–0 | Eliteserien · Norway |